gene 1,572 words KG: CFTR
Contents

CFTR Gene

🧬 Gene Info
Gene SymbolCFTR
Chromosome7q31.2
Protein TypeTransporter
Functionencodes a member of the ATP-binding cassette (ABC) transporter superfamily that functions as a cAMP-activated chloride channel.
Primary Expressionthe central nervous system where it plays important roles in neuronal function, astrocytic homeostasis, and neuroinflammation[@guggino2014]
Molecular Weight168 kDa
Amino Acids480 aa
PathwaysAkt, Autophagy, Calcium Signaling, Mapk, Mtor
UniProt IDP13569
NCBI Gene ID1080
Ensembl IDENSG00000001626
OMIM602421
GeneCardsCFTR
Human Protein AtlasCFTR
Official SymbolCFTR
Associated DiseasesAls, Cancer, Copd, Cystic Fibrosis, Fibrosis, Hypertension
InteractionsSQSTM1, RPS6KB1, GRB2, RHEB, STING1, EIF2A
KG Connections430 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Glycine-Rich Domain Competitive Inhibition
Score: 0.43
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Autophagosome Maturation Checkpoint Control
Score: 0.49
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40

See Also (8)

ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: regulates
ATF6 - Activating Transcription Factor 6
gene · KG edge: regulates
AQP1 Gene
gene · KG edge: associated_with
APC Gene
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

CFTR activates CGAS
CFTR activates JNK
CFTR provides_data_for ds-83b31ef18d49
CFTR interacts_with SQSTM1
CFTR interacts_with RPS6KB1
CFTR interacts_with GRB2
CFTR interacts_with RHEB
CFTR interacts_with STING1
CFTR interacts_with EIF2A
CFTR interacts_with LRRK2