gene

IRF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

456Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

IRF3 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with AD, ALI, ALS. Connected to 292 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IRF3
Chromosome	19q13.33
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most cell types, including: - Neurons and astrocytes in the brain - Microglia - Pe
Molecular Weight	47 kDa
Amino Acids	424 aa
Exons	10
Pathways	Akt, Autophagy, Innate Immunity, Nf-Κb, Pi3K
NCBI Gene ID	7099
GeneCards	IRF3
Human Protein Atlas	IRF3
Disease	Mechanism
Alzheimer's Disease	Neuroinflammation, microglial activation
Parkinson's Disease	α-Synuclein-induced inflammation
Associated Diseases	AD, ALI, ALS, Atherosclerosis, Infection
Interactions	PARP1, TBK1, EZH2, CCL5, VDAC1, MAX
KG Connections	456 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Virus["Viral RNA / cGAS-STING"] -->|"Activates"| TBK1["TBK1 Kinase"]
    TBK1 -->|"Phosphorylates"| IRF3["IRF3 Transcription Factor"]
    IRF3 -->|"Induces"| IFN["Type I Interferons"]
    IRF3 -->|"Activates"| CCL5["CCL5 / RANTES"]
    IRF3 -->|"Activates"| Apoptosis["Apoptosis"]
    IRF3 -->|"Activates"| Autophagy["Autophagy"]
    IRF3 -->|"Activates"| AKT1["AKT1 Survival"]
    IRF3 -->|"Cross-talks"| EGFR["EGFR Pathway"]
    IRF3 -->|"Regulates"| Chromatin["Chromatin Remodeling"]
    IRF3 -.Neuroinflammation.-> AD["Alzheimer's Disease"]
    IRF3 -.Dual role.-> Cancer["Cancer: Suppressor and Promoter"]

Outgoing (302)

Target	Relation	Type	Str
STING	activates	gene	1.00
CGAS	activates	gene	1.00
CGAS-STING	activates	gene	1.00
DNA	activates	gene	1.00
Als	activates	disease	0.95
IFN	activates	protein	0.94
type I interferon	associated_with	protein	0.90
Type I Interferon Expression	activates	process	0.90
Inflammatory Phenotype	associated_with	phenotype	0.90
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
Infection	activates	disease	0.85
TBK1	activates	gene	0.80
Innate Immunity	activates	pathway	0.80
Immune Response	activates	pathway	0.80
Toll-Like Receptor	activates	pathway	0.80
GENES	activates	gene	0.80
Inflammation	activates	disease	0.75
Fibrosis	activates	disease	0.75
Inflammation	inhibits	disease	0.75
Infection	implicated_in	disease	0.75
SMC	regulates	cell_type	0.72
CGAS	regulates	gene	0.70
CGAS	inhibits	gene	0.70
TBK1	inhibits	gene	0.70
Nf-Κb	regulates	pathway	0.70
Autophagy	activates	pathway	0.70
Nf-Κb	activates	pathway	0.70
Autophagy	regulates	pathway	0.70
MTDNA	activates	gene	0.70
CANCER	activates	gene	0.70
MTDNA	inhibits	gene	0.70
Oxidative Stress	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
TNF-Α	inhibits	gene	0.70
DNA	inhibits	gene	0.70
CGAS-STING	inhibits	gene	0.70
CGAS-STING	regulates	gene	0.70
Invasion	activates	pathway	0.70
NF-kB signaling	participates_in	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Cancer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	activates	disease	0.65

Incoming (154)

Source	Relation	Type	Str
TBK1	activates	gene	1.00
STING1	activates	protein	0.90
ZBP1	interacts_with	protein	0.90
TLR2	inhibits	protein	0.80
STING	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
YTHDF2 degradation	regulates	phenotype	0.70
MAVS	activates	gene	0.70
TNF	inhibits	gene	0.70
DSDNA	activates	gene	0.70
MITOCHONDRIAL DNA	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
NF-ΚB	activates	gene	0.70
NF-ΚB	regulates	gene	0.70
CYTOKINES	activates	gene	0.70
INFLAMMATION	inhibits	gene	0.70
RAS	activates	gene	0.70
TBK1	phosphorylates	protein	0.64
MAX	inhibits	gene	0.60
CGAS	activates	gene	0.60
PARP1	inhibits	gene	0.60
SQSTM1	activates	gene	0.60
EZH2	activates	gene	0.60
MAP3K4	regulates	gene	0.60
GADD45G	regulates	gene	0.60
P62	activates	gene	0.60
OPTN	activates	gene	0.60
RAD18	activates	gene	0.60
CXCL10	activates	gene	0.60
STING	inhibits	gene	0.60
CGAS	inhibits	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
TFAM	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
TAX1BP1	regulates	gene	0.60
P62	regulates	gene	0.60
NBR1	regulates	gene	0.60
TBK1	regulates	gene	0.60
OPTN	regulates	gene	0.60
NDP52	regulates	gene	0.60
STING	regulates	gene	0.60
EGFR	activates	gene	0.60
GAT3	activates	gene	0.60
GAT1	activates	gene	0.60
GSDMD	activates	gene	0.60
BAX	inhibits	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IRF3

Understanding Entity Pages

Summary

Wiki Pages (21)

IRF3 Gene

Neuroinflammation-Mitochondria Crosstalk Pathway

Neuroinflammation Across AD, PD, ALS, FTD, and HD

cGAS-STING Signaling in Parkinson's Disease

IL28B (Interleukin 28B)

Microglia Activation Mechanism

DNA Sensing Pathways in Neurodegeneration

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

Neuroinflammation in Neurodegeneration

Interferon Signaling in Neurodegeneration

ASC (PYCARD)

ZBP1 (Z-DNA Binding Protein 1)

cGAS-STING Pathway in Neurodegeneration

S100 Protein Signaling Pathway in Neurodegeneration

herc5

cGAS-STING Inhibitors for Parkinson's Disease

CD14 — CD14 Molecule

Innate Immune Pattern Recognition in 4R-Tauopathies

IL1RL1 Gene

cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneration

TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failure and Innate Immune Dysregulation in FTD/ALS