protein 576 words KG: NUCLEOLIN 2026-03-16
kind:proteinsection:proteinsstate:published
Contents

Nucleolin Protein

🔬 Protein Info
Gene SymbolNCL
AliasesNUCLEOLIN
Protein FamilyNucleolin Family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionproliferating cancer cells - Promotes angiogenesis via VEGF - Cell surface nucleolin targeted by anticancer drugs (e
Subcellular LocalizationNucleolus, Nucleus, Cytoplasm, Cell Surface
Molecular Weight76 kDa (primary isoform)
PathwaysApoptosis, Chromatin Remodeling, DNA Replication
UniProt IDP19367
GeneCardsNCL
Human Protein AtlasNCL
GeneNCL
PDB Structures2K3E, 2JSS
Associated DiseasesAlzheimer'S Disease, Autoimmune, DISEASES, cancer, disease
InteractionsSRPK1, TAF15, HNRPU, HNRNPA2B1, RNA, AND
KG Connections60 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: biomarker_for
Alzheimer Indonesia
institution · KG edge: biomarker_for
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

NUCLEOLIN involved_in Chromatin Remodeling
NUCLEOLIN regulates Gene Expression
NUCLEOLIN involved_in DNA Replication
NUCLEOLIN modulates Cell Proliferation
NUCLEOLIN inhibits SRPK1
NUCLEOLIN inhibits TAF15
NUCLEOLIN inhibits cancer
NUCLEOLIN associated_with cancer
NUCLEOLIN inhibits HNRPU
NUCLEOLIN inhibits HNRNPA2B1