| Gene Symbol | HSP90B1 |
| Full Name | Heat Shock Protein 90 Beta Family Member 1 |
| Chromosome | 15q26.3 |
| Function | GRP94 (encoded by HSP90B1) is a member of the heat shock protein 90 family, distinguished by its ER-resident localization and unique client protein repertoire |
| Molecular Weight | 90 kDa |
| Pathways | Mapk |
| UniProt ID | P14625 |
| NCBI Gene ID | 27197 |
| OMIM | 611719 |
| GeneCards | HSP90B1 |
| Human Protein Atlas | HSP90B1 |
| Protein Folding | HSP90B1 assists in the folding and assembly of numerous client proteins, particularly those destined for secretion or membrane insertion. |
| Quality Control | Misfolded proteins are retained in the ER and targeted for ER-associated degradation (ERAD) if folding cannot be achieved. |
| Calcium Binding | HSP90B1 acts as a major calcium-binding protein in the ER, regulating calcium homeostasis. |
| ER Stress Response | HSP90B1 is upregulated during ER stress and participates in the unfolded protein response (UPR). |
| Associated Diseases | neurodegeneration |
| Interactions | EGFR, HSPA4, FOXO1, HSP90AA1, PRKACB, PIK3R1 |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsHPASTRING |