gene

GNB4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNB4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections
0Hypotheses
0Analyses
24Outgoing
24Incoming

Summary

GNB4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Als, Cancer, Colorectal Cancer. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGNB4
Full NameG protein subunit beta 4
Chromosome16q22.1
FunctionThe G protein complex consists of three subunits that function as a molecular switch
Molecular Weight~37 kDa
Amino Acids340 aa
PathwaysMapk
UniProt IDQ9HAV0
NCBI Gene ID59345
Ensembl IDENSG00000132688
OMIM612731
GeneCardsGNB4
Human Protein AtlasGNB4
Protein Length340 amino acids
Associated DiseasesAls, Inflammation, Ms, Neurodegeneration, Neuropathy
InteractionsHSP90B1, EGFR, HSPA4, FOXO1, HSP90AA1, PRKACB
KG Connections48 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GNB4 — AlphaFold Q9HAV0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

GNB4 Gene — G Protein Subunit Beta 4

gene · 1675 words

GNB4 Protein — G Protein Subunit Beta 4

protein · 2562 words

GNG3 Protein

protein · 1874 words

QSOX1 Gene

gene · 1291 words

PSMB9

gene · 1108 words

Claustrum Neurons

cell · 1029 words

Pathway Diagram

graph TD
    GNB4["<b>GNB4</b>"]
    Inflammation{"Inflammation"}
    GNB4 -->|"associated with"| Inflammation
    Neuropathy{"Neuropathy"}
    GNB4 -->|"associated with"| Neuropathy
    Neurodegeneration{"Neurodegeneration"}
    GNB4 -->|"associated with"| Neurodegeneration
    Als{"Als"}
    GNB4 -->|"associated with"| Als
    Ms{"Ms"}
    GNB4 -->|"associated with"| Ms
    NEURODEGENERATION["NEURODEGENERATION"]
    GNB4 -->|"associated with"| NEURODEGENERATION
    IL1B["IL1B"]
    GNB4 -->|"associated with"| IL1B
    CCL5["CCL5"]
    GNB4 -->|"regulates"| CCL5
    INFLAMMATION["INFLAMMATION"]
    GNB4 -->|"associated with"| INFLAMMATION
    SQSTM1["SQSTM1"]
    GNB4 -->|"associated with"| SQSTM1
    AUTOPHAGY["AUTOPHAGY"]
    GNB4 -->|"associated with"| AUTOPHAGY
    APOPTOSIS["APOPTOSIS"]
    GNB4 -->|"associated with"| APOPTOSIS
    NFKB["NFKB"]
    NFKB -->|"associated with"| GNB4
    BCL2["BCL2"]
    BCL2 -->|"associated with"| GNB4
    PSMB9["PSMB9"]
    PSMB9 -->|"associated with"| GNB4
    style GNB4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

TargetRelationTypeStr
Inflammationassociated_withdisease0.65
Neuropathyassociated_withdisease0.65
Neurodegenerationassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (24)

SourceRelationTypeStr
BCL2associated_withgene0.60
PSMB9associated_withgene0.60
HSP90B1activatesgene0.60
PI3Kregulatesgene0.60
EGFRactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found