Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNB4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNB4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Als, Cancer, Colorectal Cancer. Connected to 49 entities in the SciDEX knowledge graph.
| Gene Symbol | GNB4 |
| Full Name | G protein subunit beta 4 |
| Chromosome | 16q22.1 |
| Function | The G protein complex consists of three subunits that function as a molecular switch |
| Molecular Weight | ~37 kDa |
| Amino Acids | 340 aa |
| Pathways | Mapk |
| UniProt ID | Q9HAV0 |
| NCBI Gene ID | 59345 |
| Ensembl ID | ENSG00000132688 |
| OMIM | 612731 |
| GeneCards | GNB4 |
| Human Protein Atlas | GNB4 |
| Protein Length | 340 amino acids |
| Associated Diseases | Als, Inflammation, Ms, Neurodegeneration, Neuropathy |
| Interactions | HSP90B1, EGFR, HSPA4, FOXO1, HSP90AA1, PRKACB |
| KG Connections | 48 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GNB4["<b>GNB4</b>"]
Inflammation{"Inflammation"}
GNB4 -->|"associated with"| Inflammation
Neuropathy{"Neuropathy"}
GNB4 -->|"associated with"| Neuropathy
Neurodegeneration{"Neurodegeneration"}
GNB4 -->|"associated with"| Neurodegeneration
Als{"Als"}
GNB4 -->|"associated with"| Als
Ms{"Ms"}
GNB4 -->|"associated with"| Ms
NEURODEGENERATION["NEURODEGENERATION"]
GNB4 -->|"associated with"| NEURODEGENERATION
IL1B["IL1B"]
GNB4 -->|"associated with"| IL1B
CCL5["CCL5"]
GNB4 -->|"regulates"| CCL5
INFLAMMATION["INFLAMMATION"]
GNB4 -->|"associated with"| INFLAMMATION
SQSTM1["SQSTM1"]
GNB4 -->|"associated with"| SQSTM1
AUTOPHAGY["AUTOPHAGY"]
GNB4 -->|"associated with"| AUTOPHAGY
APOPTOSIS["APOPTOSIS"]
GNB4 -->|"associated with"| APOPTOSIS
NFKB["NFKB"]
NFKB -->|"associated with"| GNB4
BCL2["BCL2"]
BCL2 -->|"associated with"| GNB4
PSMB9["PSMB9"]
PSMB9 -->|"associated with"| GNB4
style GNB4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | associated_with | disease | 0.65 |
| Neuropathy | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Melanoma | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Colorectal Cancer | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| IL1B | associated_with | gene | 0.60 |
| CCL5 | regulates | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| GBA | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| Proteasome | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Endocytosis | associated_with | pathway | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BCL2 | associated_with | gene | 0.60 |
| PSMB9 | associated_with | gene | 0.60 |
| HSP90B1 | activates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| HSPA4 | activates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| HSP90AA1 | activates | gene | 0.60 |
| PRKACB | activates | gene | 0.60 |
| PIK3R1 | activates | gene | 0.60 |
| IGF1 | activates | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| QSOX1 | activates | gene | 0.60 |
| LAMB2 | activates | gene | 0.60 |
| WNT4 | activates | gene | 0.60 |
| LGALS1 | activates | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| NFKB | associated_with | gene | 0.60 |
| DIABETES MELLITUS | regulates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ERBB2 | activates | gene | 0.60 |
| AXON | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||