concept

ERBB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERBB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

464Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ERBB2 is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Als, Atherosclerosis, Cancer. Connected to 238 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ERBB2
Key Genes/Proteins	ERBB3
Related Diseases	Breast Cancer, Gastric Cancer, Gallbladder Cancer, Metastatic Colorectal Cancer, Cancer
Related Pathways	Her2 Signaling Pathway

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ERBB2["ERBB2"]
    ERBB2 -->|"activates"| Cancer["Cancer"]
    ERBB2 -->|"activates"| Tumor["Tumor"]
    ERBB2 -->|"activates"| Ms["Ms"]
    ERBB2 -->|"target for"| Inflammation["Inflammation"]
    ERBB2 -->|"target for"| Als["Als"]
    ERBB2 -->|"interacts"| Atherosclerosis["Atherosclerosis"]
    ERK["ERK"] -->|"activates"| ERBB2
    GAIN["GAIN"] -->|"activates"| ERBB2
    PHGDH["PHGDH"] -->|"activates"| ERBB2
    ACAT1["ACAT1"] -->|"activates"| ERBB2
    PI3K["PI3K"] -->|"activates"| ERBB2
    AKT["AKT"] -->|"activates"| ERBB2
    ELF3["ELF3"] -->|"target for"| ERBB2
    TFEB["TFEB"] -->|"activates"| ERBB2
    TFE3["TFE3"] -->|"activates"| ERBB2

Outgoing (297)

Target	Relation	Type	Str
Breast Cancer	associated_with	disease	0.98
Gastric Cancer	associated_with	disease	0.98
Gallbladder Cancer	associated_with	disease	0.95
Trastuzumab Deruxtecan	targets	drug	0.95
Cell Proliferation	regulates	process	0.95
Cell Survival	regulates	process	0.95
Cell Differentiation	regulates	process	0.95
Her2 Signaling Pathway	involved_in	pathway	0.93
Her2-Low Status	associated_with	biomarker	0.90
ERBB3	interacts_with	protein	0.90
Metastatic Colorectal Cancer	expressed_in	disease	0.88
Cancer	therapeutic_target	disease	0.85
Tumor	therapeutic_target	disease	0.85
Als	therapeutic_target	disease	0.85
Cell Proliferation	activates	process	0.85
Gallbladder Cancer	biomarker_for	disease	0.85
ovarian cancer	biomarker_for	disease	0.85
Triple-Negative Breast Cancer	biomarker_for	disease	0.85
Metastatic Breast Cancer	biomarker_for	disease	0.85
Immunohistochemistry Expression	involved_in	process	0.85
PI3K/AKT Signaling	downregulates	pathway	0.80
RAS/MAPK/ERK Signaling	downregulates	pathway	0.80
PI3K/AKT Signaling	modulates	pathway	0.80
RAS/MAPK/ERK Signaling	modulates	pathway	0.80
Cancer	activates	disease	0.75
Als	associated_with	disease	0.75
Als	activates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
Autophagy	activates	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Mapk	regulates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
RAS	activates	gene	0.70
CANCER	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Neuropathy	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
Glioblastoma	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Cancer	contributes_to	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Als	regulates	disease	0.65
Obesity	regulates	disease	0.65

Incoming (167)

Source	Relation	Type	Str
EGFR	activates	gene	0.80
PI3K	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
MMP9	therapeutic_target	gene	0.70
AKT1	therapeutic_target	gene	0.70
PI3K	regulates	gene	0.70
ERK	activates	gene	0.60
GAIN	activates	gene	0.60
PHGDH	activates	gene	0.60
ACAT1	activates	gene	0.60
ACAT1	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
ELF3	therapeutic_target	gene	0.60
TFEB	activates	gene	0.60
TFE3	activates	gene	0.60
RET	inhibits	gene	0.60
BCL2	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
HIF1A	therapeutic_target	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
EGF	interacts_with	gene	0.60
NOX1	interacts_with	gene	0.60
MET	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TP53	regulates	gene	0.60
CANCER	activates	gene	0.60
EGFR	contributes_to	gene	0.60
ERBB3	associated_with	gene	0.60
ERK	regulates	gene	0.60
MYC	activates	gene	0.60
AKT	regulates	gene	0.60
AKT1	regulates	gene	0.60
CANCER	regulates	gene	0.60
ERK1	regulates	gene	0.60
CD44	activates	gene	0.60
XBP1	activates	gene	0.60
CANCER	expressed_in	gene	0.60
BCL2L1	associated_with	gene	0.60
SRC	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
NFKB	regulates	gene	0.60
MTOR	regulates	gene	0.60
IL6	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ERBB2

Understanding Entity Pages

Summary

Wiki Pages (16)

Growth Factor Therapeutics: Investment Landscape Analysis

Schwann Cells in Peripheral Neuropathy

EGFR Signaling in Parkinson's Disease

nrg3-protein

NRG2 Protein

EGFR — Epidermal Growth Factor Receptor

PD EGFR Signaling Therapy Companies

Schwann Cells (Peripheral Nervous System)

LATS2

ADAM19 Gene

NRG1 Protein

CAMK2G — Calcium/Calmodulin-Dependent Kinase 2 Gamma

Schwann Cells

ERBB3 (HER3) Protein