gene 2,024 words KG: IL11 2026-03-21
kind:genesection:genesstate:published
Contents

IL11 Gene

🧬 Gene Info
Gene SymbolIL11
AliasesAGIF, OPN, oprelvekin
Chromosome19q13.4
Protein TypeIL-6 family cytokine
FunctionIL-11 has diverse biological functions spanning multiple organ systems:
Primary Expressionvarious cell types and has been implicated in neuroinflammation, astrocyte function, and neurodegenerative diseases[@du2016][@gadient1998][@schwab2021
Molecular Weight~19 kDa
Amino Acids199 aa
PathwaysApoptosis, Metastasis, Tumor Microenvironment, osteoblastogenesis
UniProt IDP20815
NCBI Gene ID3609
OMIM147681
GeneCardsIL11
Human Protein AtlasIL11
Protein ClassIL-6 family cytokine
Associated Diseasesneurodegeneration
InteractionsIL11R, EGFR, CD8, APOPTOSIS, CANCER, ASTROCYTES
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: associated_with
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
MTOR Gene
gene · KG edge: associated_with
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates
CD8 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

IL11 interacts_with IL11R
IL11 activates osteoblastogenesis
IL11 associated_with STAT3
IL11 therapeutic_target Fibrosis
IL11 therapeutic_target Inflammation
IL11 associated_with Mtor
IL11 activates Tumor
IL11 activates Cancer
IL11 activates Lung Cancer
IL11 activates Metastasis