gene 1,488 words KG: STAT3 2026-03-26
kind:genesection:genesstate:published
Contents

STAT3 Gene

🧬 Gene Info
Gene SymbolSTAT3
Full NameSignal Transducer and Activator of Transcription 3
Chromosome17q21.2
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~92 kDa
Amino Acids770 aa
PathwaysAkt, Amyloid, Angiogenesis, Apoptosis, Autophagy
UniProt ID[P40763](https://www.uniprot.org/uniprot/P40763)
NCBI Gene ID6776
Ensembl IDENSG00000168610
OMIM102582
GeneCardsSTAT3
Human Protein AtlasSTAT3
Protein Length770 amino acids
Associated DiseasesASTROGLIOSIS, Aging, Als, Alzheimer, Alzheimer'S Disease
Known Drugs/CompoundsBARICITINIB, RAPAMYCIN, Shexiang Baoxin pill, SD36, Dimethyl Fumarate, resveratrol
InteractionsIFNG, LC3, RPTOR, RB1, EIF2AK3, RIPK1
KG Connections3630 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Aquaporin-4 Polarization Rescue
Score: 0.51
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.68
SASP-Mediated Complement Cascade Amplification
Score: 0.73
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Transcriptional Autophagy-Lysosome Coupling
Score: 0.68

Related Analyses (21)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (2)

S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
AIFM1 Gene
gene · KG edge: activates
AGO2 (Argonaute-2)
gene · KG edge: inhibits
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates

Knowledge Graph (12 edges)

STAT3 associated_with TFEB
STAT3 associated_with RB1
STAT3 co_discussed STING
STAT3 upregulates TNF
STAT3 inhibits TFEB
STAT3 regulates GSDME
STAT3 phosphorylates IL6
STAT3 mediates IL-2 SIGNALING
STAT3 phosphorylates STING1
STAT3 phosphorylates TFE3