gene 1,488 words KG: STAT3
Contents

STAT3 Gene

🧬 Gene Info
Gene SymbolSTAT3
Full NameSignal Transducer and Activator of Transcription 3
Chromosome17q21.2
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight92 kDa
Amino Acids770 aa
PathwaysAkt, Amyloid, Angiogenesis, Apoptosis, Autophagy
UniProt ID[P40763](https://www.uniprot.org/uniprot/P40763)
Ensembl IDENSG00000168610
GeneCardsSTAT3
Human Protein AtlasSTAT3
Associated Diseasesacute lung injury, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsAcetyl-CoA, BARICITINIB, Benzo[a]pyrene, curcumin, Curcumin, dimethyl fumarate
InteractionsABCG2, acetyl-CoA, ACETYL-COA, ACHE, ACSL4, Actin
SciDEX HypothesesSpinal Cord Astrocyte Reactivity Convergence
Dual Astrocyte-Microglia Phenotype Synchronization
KG Connections3626 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (68)

Aquaporin-4 Polarization Rescue
Score: 0.73
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89
SASP-Mediated Complement Cascade Amplification
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
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Related Analyses (20)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (6)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulates
AGO2 (Argonaute-2)
gene · KG edge: inhibits
AIFM1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

IL6 activates STAT3
STAT3 activates VAV1
GPCR regulates STAT3
STAT3 regulates MITOCHONDRION
TSPAN8 interacts_with STAT3
STAT3 regulates MMP9
STAT3 regulates MYC
STAT3 regulates BCL2
TRF33 inhibits STAT3
STAT3 activates GASTRIC_CANCER

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