| Gene Symbol | ITPR2 |
| Function | IP3R2 is one of three mammalian IP3 receptor isoforms |
| Primary Expression | neurons and endocrine cells - Channel Properties: Forms tetrameric channels (~1 |
| Molecular Weight | 270 kDa |
| Ensembl ID | ENSG00000123104 |
| GeneCards | ITPR2 |
| Human Protein Atlas | ITPR2 |
| Calcium Release Channel | Opens in response to IP3 binding, releasing Ca²⁺ from ER stores |
| Calcium Signaling | Generates cytosolic Ca²⁺ waves for various cellular processes |
| Tissue Distribution | Predominantly expressed in neurons and endocrine cells |
| Channel Properties | Forms tetrameric channels (~1.4 MDa) |
| Neuronal Calcium Signaling | Regulates Ca²⁺ dynamics in neurons |
| Synaptic Plasticity | Ca²⁺ release affects LTP, LTD, and neurotransmitter release |
| Gene Expression | Ca²⁺ influx activates transcription factors (CREB, NFAT) |
| Metabolism | Links G-protein signaling to metabolic responses |
| Associated Diseases | Infection, Parkinson, Viral Infection |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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