gene 607 words KG: NFKB1 2026-03-21
kind:genesection:genesstate:published
Contents

NFKB1 Gene

🧬 Gene Info
Gene SymbolNFKB1
Full NameNuclear Factor Kappa B Subunit 1
Chromosome4q24
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionNFKB1 encodes p105, which is processed to p50, a DNA-binding subunit of NF-κB.
Molecular Weight105 kDa (p105), 50 kDa (p50)
Amino Acids968 aa
PathwaysNfkb, NFKB, NF-κB, NF-κB pathway
UniProt IDP19838
NCBI Gene ID4790
Ensembl IDENSG00000109320
OMIM164011
GeneCardsNFKB1
Human Protein AtlasNFKB1
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Cancer, Carcinoma
Known Drugs/CompoundsBerberine, Electroacupuncture, Xiyangshen Sanqi Danshen Granules
InteractionsIL30, PINK1, APP, PTEN, RELA, BACE1
KG Connections420 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Perinatal Hypoxia-Primed Microglia Targeting
Score: 0.38
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Purinergic Signaling Polarization Control
Score: 0.55

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (2)

Resveratrol protection against renal I/R injury in diabetic
validation · proposed · Score: 0.90
Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio
exploratory · proposed · Score: 0.85

See Also (7)

Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
ANG — Angiogenin
gene · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (12 edges)

NFKB1 protects_against PPARG
NFKB1 therapeutic_target TRIM24
NFKB1 therapeutic_target TDP1
NFKB1 therapeutic_target MAPK1
NFKB1 therapeutic_target CTSD
NFKB1 therapeutic_target HIF1A
NFKB1 regulates microglial inflammation
NFKB1 associated_with STAT3
NFKB1 associated_with TNF
NFKB1 associated_with RAB7A