gene 2,543 words KG: P2RY1 2026-03-31
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammationtopic:platelets
Contents

P2RY1 Gene

🧬 Gene Info
Gene SymbolP2RY1
Full NamePurinergic Receptor P2Y1
Chromosome19
Protein FamilyP2Y receptor family (GPCR)
Protein TypeGpcr
Target ClassGpcr
FunctionGPCR antagonists or agonists modulating purinergic signaling
Mechanism of ActionGPCR antagonists or agonists modulating purinergic signaling
DruggabilityLow (0.41)
Clinical StagePhase I
Molecular Weight41 kDa
Exons2
PathwaysSpontaneous Bursting Activity
UniProt IDP47900
NCBI Gene ID5028
Ensembl IDENSG00000142203
OMIM181010
GeneCardsP2RY1
Human Protein AtlasP2RY1
Associated DiseasesALS, ALZHEIMER, Epilepsy, Focal Cortical Dysplasia, Hippocampal Sclerosis
Known Drugs/CompoundsMRS2500
InteractionsP2RX7, P2RX5, PANX1, ADORA2B, P2RX4, P2RX1
SciDEX TargetView Target Profile (2 clinical trials)
KG Connections234 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (26)

Purinergic Signaling Polarization Control
Score: 0.55
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Multi-Modal Stress Response Harmonization
Score: 0.60
Microbial Inflammasome Priming Prevention
Score: 0.58

Related Analyses (12)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (2)

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
P2RX7 variant rs1718119 association with glucose homeostasis
exploratory · proposed · Score: 0.90

See Also (12)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: co_discussed
HK2
gene · KG edge: co_discussed
DGAT1 — Diacylglycerol O-Acyltransferase 1
gene · KG edge: co_discussed
CD38 Molecule (CD38)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

P2RY1 expressed_in LUNG TISSUE
P2RY1 upregulates UPREGULATES
P2RY1 regulates GLUCOSE HOMEOSTASIS
P2RY1 regulates P2RY12
P2RY1 regulates PANX1
P2RY1 expressed_in IMMUNE CELLS
P2RY1 therapeutic_target THERAPEUTIC_TARGET
P2RY1 associated_with neurodegeneration
P2RY1 interacts_with P2RX7
P2RY1 co_discussed SOAT1