protein 613 words KG: NFKB1
Contents

NF-κB p105/p50 Protein

🔬 Protein Info
Gene SymbolNF
Full NameκB p105/p50 Protein
AliasesNFKB1
FunctionNf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCardsNF
Human Protein AtlasNF
Associated DiseasesAls, Alzheimer, Alzheimer'S Disease, Cancer, Carcinoma
Known Drugs/CompoundsBerberine, Electroacupuncture, Xiyangshen Sanqi Danshen Granules
InteractionsALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID, ANG
SciDEX HypothesesDual NF-κB/MMP Inhibition Strategy
Inflammaging-Epigenome Decoupling Strategy
KG Connections417 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (13)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Circadian Clock-Autophagy Synchronization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Purinergic Signaling Polarization Control
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (13)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Blood-brain barrier tight junction disruption by neuroinflam
neurodegeneration · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (2)

Resveratrol protection against renal I/R injury in diabetic
validation · proposed · Score: 0.90
Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio
exploratory · proposed · Score: 0.85

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
ANG — Angiogenin
gene · KG edge: activates

Knowledge Graph (12 edges)

hyperoxia activates NFKB1
TNF activates NFKB1
TRAF6 activates NFKB1
NFKB1 regulates TNF
NFKB1 regulates IL1B
NFKB1 therapeutic_target TRIM24
NFKB1 therapeutic_target TDP1
NFKB1 therapeutic_target MAPK1
NFKB1 therapeutic_target CTSD
NFKB1 therapeutic_target HIF1A

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