gene 2,340 words KG: CTNNB1
Contents

CTNNB1 — Catenin Beta 1

🧬 Gene Info
Gene SymbolCTNNB1
Full NameCatenin Beta 1
Chromosome3p22.1
Primary ExpressionUbiquitous, highest in brain
Molecular Weight85 kDa
Amino Acids781 aa
PathwaysWnt signaling, Wnt, Wnt pathway
UniProt IDP35222
NCBI Gene ID1499
Ensembl IDENSG00000100994
OMIM116806
GeneCardsCTNNB1
Human Protein AtlasCTNNB1
Associated DiseasesAls, Alzheimer, Blood-Brain Barrier Integrity, Breast Cancer, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsTP53, TERT, PI3K, AKT, ANO1, ATG7
KG Connections503 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Inhibitory Neuron-Selective WNT Signaling Restoration
Score: 0.39
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Which cell types show the most significant expression change
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in
ARID1A
gene · KG edge: associated_with
APC Gene
gene · KG edge: associated_with
ANO1 (Anoctamin 1 (TMEM16A))
gene · KG edge: activates
ALDH1A1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CTNNB1 activates GAPDH
CTNNB1 activates GSK3B
CTNNB1 activates LAMP1
CTNNB1 activates MTOR
CTNNB1 activates RAB7A
CTNNB1 activates SQSTM1
CTNNB1 activates TCF4
CTNNB1 encodes beta-catenin
CTNNB1 associated_with AXIN2
CTNNB1 associated_with GAPDH