gene 1,229 words KG: HSPA8
Contents

HSPA8 Gene

🧬 Gene Info
Gene SymbolHSPA8
Full NameHeat Shock Protein Family A (Hsp70) Member 8
Chromosome9q33.3
FunctionHsc70 participates in multiple cellular processes:
Molecular Weight71 kDa
Amino Acids646 aa
PathwaysAutophagy
UniProt ID[P11142](https://www.uniprot.org/uniprot/P11142)
Ensembl IDENSG00000143371
GeneCardsHSPA8
Human Protein AtlasHSPA8
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, Ataxia, Atherosclerosis, Cancer
Known Drugs/Compoundsrapamycin
InteractionsCALCINEURIN, ATG12, ATG10, TMEM63A, VCP, DERL1
KG Connections500 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Autophagosome Maturation Checkpoint Control
Score: 0.49
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
ATG12 — Autophagy Related 12
gene · KG edge: activates
ATG10 Gene
gene · KG edge: activates
ar
gene · KG edge: activates

Knowledge Graph (12 edges)

HSPA8 associated_with MCOLN1
HSPA8 associated_with SQSTM1
HSPA8 associated_with SOD1
HSPA8 associated_with BCL2
HSPA8 associated_with CTSB
HSPA8 associated_with TPP1
HSPA8 associated_with GLA
HSPA8 activates CALCINEURIN
HSPA8 activates ATG12
HSPA8 associated_with STUB1