| Gene Symbol | MSH3 |
| Full Name | MutS Homolog 3 |
| Chromosome | 5q31.1 |
| Function | MSH3 (MutS Homolog 3) encodes a key DNA mismatch repair (MMR) protein that forms the MutSβ heterodimer with MSH2. |
| Pathways | Apoptosis, Dna Repair, Epigenetic |
| UniProt ID | [P54205](https://www.uniprot.org/uniprot/P54205) |
| Ensembl ID | ENSG00000110899 |
| GeneCards | MSH3 |
| Human Protein Atlas | MSH3 |
| MSH3 inhibitors | Under investigation for cancer combination therapy |
| Gene therapy | AAV-delivered MSH3 for neuroprotection |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Cancer, Colorectal Cancer |
| Interactions | DNA, FAN1, HTT, LIG1, MLH1, MSH2 |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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