SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
gene 624 words KG: LRP10
Contents

LRP10

🧬 Gene Info
Gene SymbolLRP10
Protein TypeReceptor
FunctionLRP10 is a transmembrane receptor protein involved in
Primary Expressionneurons and has been implicated in endosomal-lysosomal trafficking and protein clearance pathways
GeneCardsLRP10
Human Protein AtlasLRP10
Associated DiseasesParkinson's disease
InteractionsALZHEIMER'S DISEASE, APP, ENDOSOMES, SORL1
KG Connections30 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71LRP1-Dependent Tau Uptake Disruption
Score: 0.60Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Extracellular Vesicle Biogenesis Modulation
Score: 0.58

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activatesMicroglia
cell · KG edge: expressed_inAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_withAlzheimer Indonesia
institution · KG edge: expressed_inLDLR Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

APOE associated_with LRP10
LRP10 associated_with LDLR
LRP10 activates APP
LRP10 associated_with TREM2
LRP10 expressed_in TREM2
LRP10 expressed_in APOE
APOE expressed_in LRP10
LRP10 expressed_in Rb
LRP10 activates neurodegeneration
LRP10 interacts_with SORL1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas