gene 855 words KG: LRP12 2026-03-27
kind:genesection:genesstate:published
Contents

LRP12 — Low Density Lipoprotein Receptor-Related Protein 12

🧬 Gene Info
Gene SymbolLRP12
Full NameLow Density Lipoprotein Receptor-Related Protein 12
AliasesPage for LRP12
Chromosome8q22.3
Protein TypeReceptor
Functionis a member of the LDL receptor family involved in lipoprotein metabolism, cell signaling, and synaptic function.
Primary Expressionvarious tissues, including brain regions critical for learning and memory [@lrpa]
Molecular Weight~182 kDa
Amino Acids2245 aa
UniProt IDQ9Y286
NCBI Gene ID50767
GeneCardsLRP12
Human Protein AtlasLRP12
Protein ClassLDL receptor family
Associated DiseasesAls, Alzheimer, Ms
KG Connections7 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (17)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
SORL1 (Redirect)
redirect · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses

Knowledge Graph (7 edges)

LRP12 associated_with Alzheimer
LRP12 associated_with Ms
LRP12 associated_with Als
LRP12 associated_with Cholesterol
LRP12 associated_with Lipid Metabolism
SOAT1 associated_with LRP12
SORL1 associated_with LRP12