gene 2,598 words KG: MAP3K4 2026-03-27
kind:genesection:genesstate:published
Contents

MAP3K4 — Mitogen-Activated Protein Kinase Kinase Kinase 4

🧬 Gene Info
Gene SymbolMAP3K4
Full NameMitogen-Activated Protein Kinase Kinase Kinase 4
AliasesJNK, p38
Chromosome6q26
Protein TypeKinase
Functionis a critical upstream regulator of stress-activated protein kinase signaling pathways.
Subcellular Localizationand substrate recognition
Molecular Weight~190 kDa
Amino Acids721 aa
PathwaysMAPK, MAPK pathway
UniProt IDQ9Y1R4
NCBI Gene ID4216
Ensembl IDENSG00000070731
OMIM602505
GeneCardsMAP3K4
Human Protein AtlasMAP3K4
Associated Diseasesneurodegeneration
InteractionsDNA
KG Connections44 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.71
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

Alzheimer Indonesia
institution · KG edge: activates
IRF3 Gene
gene · KG edge: regulates
GADD45G — Growth Arrest And DNA Damage Inducible Gamma
gene · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: regulates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: expressed_in

Knowledge Graph (12 edges)

MAP3K4 regulates GADD45G
MAP3K4 regulates IRF3
MAP3K4 regulates REL
MAP3K4 mediates Neuroimmune Signaling
MAP3K4 regulates Neurodegeneration
MAP3K4 regulates Alzheimer
MAP3K4 regulates Nf-Κb
MAP3K4 regulates DNA
MAP3K4 activates Alzheimer
MAP3K4 activates Neurodegeneration