gene 702 words KG: REL 2026-03-24
kind:genesection:genesstate:published
Contents

REL Gene

🧬 Gene Info
Gene SymbolREL
Full Namec-Rel Proto-Oncogene, NF-Kappa B Subunit
Chromosome2p16.1
FunctionREL (c-Rel) is a member of the NF-κB family that forms heterodimers with p50 and p52.
Primary Expressionhematopoietic cells, with lower expression in other tissues
PathwaysAkt, Apoptosis, Complement, Immune Response, Lipid Metabolism
UniProt IDP41160
NCBI Gene ID5966
Ensembl IDENSG00000162924
OMIM164913
GeneCardsREL
Human Protein AtlasREL
Associated DiseasesAD, ALI, AMI, Aging, Als, Inflammation
InteractionsFOXO1, CANCER, GENES, AND, IL-10, RNA
KG Connections152 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52

Related Analyses (11)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (1)

REL transcription factor mediates VLC ceramide-driven inflam
exploratory · proposed · Score: 0.75

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: protects_against
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: protects_against
HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)
gene · KG edge: regulates

Knowledge Graph (12 edges)

REL implicated_in inflammatory bowel disease
REL regulates PRDM1
REL regulates CD8
REL associated_with STAT3
REL associated_with IRF1
REL activates FOXO1
REL regulates CERS2
REL expressed_in RELA
REL expressed_in RELB
REL contributes_to RELA