gene 1,775 words KG: GADD45G 2026-03-25
kind:genesection:genesstate:published
Contents

GADD45G — Growth Arrest And DNA Damage Inducible Gamma

🧬 Gene Info
Gene SymbolGADD45G
Full NameGrowth Arrest And DNA Damage Inducible Gamma
Chromosome9q22.2
Functionis a member of the GADD45 family of stress-responsive genes, which also includes GADD45A and GADD45B.
Molecular Weight~18 kDa
Amino Acids165 aa
PathwaysMAPK signaling
UniProt IDO75217
NCBI Gene ID5154
Ensembl IDENSG00000171846
OMIM604949
GeneCardsGADD45G
Human Protein AtlasGADD45G
Gene NameGrowth Arrest and DNA Damage Inducible Gamma
Protein Length165 amino acids
Associated DiseasesAlzheimer's Disease, Synapse Loss, astrogliosis, microgliosis, synapse_loss
InteractionsIRF3, MET, DNA, NEURODEGENERATION, NEURON, NF-ΚB
KG Connections81 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68

Related Analyses (3)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (15)

Alzheimer Indonesia
institution · KG edge: expressed_in
GADD45B — Growth Arrest and DNA Damage Inducible Beta
gene · KG edge: activates
GADD45A Gene
gene · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates

Knowledge Graph (12 edges)

GADD45G activates reactive_gliosis
GADD45G activates neurodegeneration
GADD45G causes astrogliosis
GADD45G causes microgliosis
GADD45G causes synapse_loss
GADD45G activates alzheimer_disease
GADD45G regulates MAP3K4
GADD45G activates NF_kB
GADD45G activates IRF3
GADD45G regulates neuroimmune_signaling