gene 2,425 words KG: PCDH15
Contents

PCDH15 — Protocadherin 15

🧬 Gene Info
Gene SymbolPCDH15
Full Namepcdh15
Chromosome10q21.1
Protein TypeGene
Functionis a member of the cadherin superfamily of cell adhesion molecules that plays critical roles in the development and maintenance of the auditory and vestibular systems.
Primary Expressionthe stereocilia (hair bundle) of inner and outer hair cells in the cochlea - Vestibular system: Present in hair cells of the utricle, saccule, and
Subcellular Localizationthe tips of stereocilia where mechanotransduction occurs
Molecular Weight250 kDa
Amino Acids307 aa
Exons35
NCBI Gene ID65217
GeneCardsPCDH15
Human Protein AtlasPCDH15
Associated Diseasesneurodegeneration
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (2)

APOE-Dependent Autophagy Restoration
Score: 0.61
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
TPR — Translocated Promoter Region
gene · KG edge: associated_with
RB1 — Retinoblastoma 1
gene · KG edge: associated_with
PIK3CA Gene
gene · KG edge: therapeutic_target
FGFR2 — Fibroblast Growth Factor Receptor 2
gene · KG edge: associated_with

Knowledge Graph (11 edges)

PCDH15 therapeutic_target PIK3CA
PCDH15 associated_with FGFR2
PCDH15 associated_with Rb
PCDH15 therapeutic_target Als
PCDH15 therapeutic_target Cancer
PCDH15 associated_with Fgf
TPR associated_with PCDH15
ESR1 associated_with PCDH15
RB1 associated_with PCDH15
DNA therapeutic_target PCDH15