Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PBRM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PBRM1 |
| Key Genes/Proteins | Swi/Snf Complex, VHL |
| Related Diseases | Clear Cell Renal Cell Carcinoma, Kidney Cancer, VHL-Loss-Driven phenotype, biomarker_for |
| Related Pathways | SWI/SNF complex, SWI/SNF Complex |
Knowledge base pages for this entity
graph TD
PBRM1["PBRM1"]
PBRM1 -->|"inhibits"| Clear_Cell_Renal_Cell_Carcinom["Clear Cell Renal Cell Carcinoma"]
PBRM1 -->|"component_of"| SWI_SNF_Complex["SWI/SNF Complex"]
PBRM1 -->|"modulates"| VHL_Loss["VHL Loss"]
PBRM1 -->|"involved_in"| Chromatin_Remodeling["Chromatin Remodeling"]
PBRM1 -->|"involved_in"| Tumor_Suppression["Tumor Suppression"]
PBRM1 -->|"causes"| Cardiovascular["Cardiovascular"]
PBRM1 -->|"causes"| Cancer["Cancer"]
PBRM1 -->|"causes"| Carcinoma["Carcinoma"]
MTOR["MTOR"] -->|"activates"| PBRM1
CANCER["CANCER"] -->|"causes"| PBRM1
VHL["VHL"] -->|"causes"| PBRM1
HIF1["HIF1"] -->|"activates"| PBRM1
STAT3["STAT3"] -->|"activates"| PBRM1
DNA["DNA"] -->|"target for"| PBRM1| Target | Relation | Type | Str |
|---|---|---|---|
| Clear Cell Renal Cell Carcinoma | inhibits | disease | 0.95 |
| Clear Cell Renal Cell Carcinoma | suppresses | disease | 0.95 |
| SWI/SNF complex | involved_in | pathway | 0.95 |
| Clear Cell Renal Cell Carcinoma | risk_factor_for | disease | 0.90 |
| SWI/SNF Complex | component_of | pathway | 0.90 |
| Swi/Snf Complex | interacts_with | protein | 0.90 |
| VHL Loss | modulates | process | 0.85 |
| Kidney Tumorigenesis | involved_in | process | 0.85 |
| Kidney Cancer | protects_against | disease | 0.85 |
| kidney tumorigenesis | suppresses | process | 0.85 |
| VHL-Loss-Driven phenotype | associated_with | phenotype | 0.85 |
| Chromatin Remodeling | involved_in | process | 0.85 |
| Tumor Suppression | involved_in | process | 0.80 |
| biomarker_for | associated_with | phenotype | 0.80 |
| VHL | interacts_with | protein | 0.75 |
| Cardiovascular | causes | disease | 0.65 |
| Cancer | causes | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Carcinoma | causes | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| STAT3 | associated_with | gene | 0.60 |
| AND | causes | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| HIF1 | associated_with | gene | 0.60 |
| CANCER | causes | gene | 0.60 |
| VHL | causes | gene | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Rb | causes | protein | 0.60 |
| Ras | causes | protein | 0.60 |
| RB1 | associated_with | gene | 0.60 |
| PCDH15 | associated_with | gene | 0.60 |
| PIK3CA | therapeutic_target | gene | 0.60 |
| FGFR2 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| Fgf | associated_with | protein | 0.60 |
| VHL | associated_with | gene | 0.60 |
| VHL | activates | gene | 0.60 |
| SNF | causes | gene | 0.60 |
| SWI | causes | gene | 0.60 |
| cancer | causes | disease | 0.60 |
| cancer | associated_with | disease | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||