gene 540 words KG: FGFR2 2026-03-21
kind:genesection:genesstate:published
Contents

FGFR2 — Fibroblast Growth Factor Receptor 2

🧬 Gene Info
Gene SymbolFGFR2
Full NameFibroblast Growth Factor Receptor 2
Chromosome10q26
FunctionFGFR2 encodes fibroblast growth factor receptor 2, a receptor tyrosine kinase that primarily binds FGF7 and FGF10 (ligands with high specificity for FGFR2IIIb isoform).
Primary Expressionneural progenitors, astrocytes, and some neurons
PathwaysApoptosis, Chemoresistance, Stem Cell
UniProt ID[P21802](https://www.uniprot.org/uniprot/P21802)
Ensembl IDENSG00000166468
OMIM176943
GeneCardsFGFR2
Human Protein AtlasFGFR2
Associated DiseasesCancer, Cardiac, Ischemia
InteractionsEGFR, FGF7, TP53, B3GALT6, Rb, Mek
KG Connections147 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (14)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: activates
FGFR1 — Fibroblast Growth Factor Receptor 1
gene · KG edge: biomarker_for
FGF7 — Fibroblast Growth Factor 7
gene · KG edge: activates
ESR1 — Estrogen Receptor Alpha
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FGFR2 regulates GFRA1
FGFR2 inhibits EGFR
FGFR2 co_discussed PARKIN
FGFR2 activates FGF7
FGFR2 associated_with Astrocyte Reactivity
FGFR2 inhibits TP53
FGFR2 associated_with Rb
FGFR2 activates B3GALT6
FGFR2 activates Rb
FGFR2 therapeutic_target Rb