gene 2,204 words KG: RPL27A 2026-03-25
kind:genesection:genesstate:published
Contents

RPL27A — Ribosomal Protein L27A

🧬 Gene Info
Gene SymbolRPL27A
Full NameRibosomal Protein L27A
Chromosome16p13.3
Functionencodes a component of the large 60S ribosomal subunit, essential for protein synthesis in all eukaryotic cells.
Primary Expressionneurons and glia throughout the brain and spinal cord
Molecular Weight16.7 kDa
Amino Acids158 aa
Exons6
UniProt IDP46776
NCBI Gene ID6163
Ensembl IDENSG00000265391
GeneCardsRPL27A
Human Protein AtlasRPL27A
Associated Diseasesneurodegeneration
InteractionsEIF4G2
KG Connections12 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (7)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: therapeutic_target
KIF2A — Kinesin Family Member 2A
gene · KG edge: therapeutic_target
EIF4G2 Gene
gene · KG edge: interacts_with
Genes
index · KG edge: therapeutic_target
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: therapeutic_target

Knowledge Graph (12 edges)

RPL27A therapeutic_target Epilepsy
RPL27A therapeutic_target Cancer
RPL27A therapeutic_target Tumor
RPL27A therapeutic_target Ms
RPL27A therapeutic_target Oxidative Stress
RPL27A therapeutic_target Wnt
RPL27A therapeutic_target CANCER
RPL27A therapeutic_target OXIDATIVE STRESS
KIF2A therapeutic_target RPL27A
EIF4G2 interacts_with RPL27A