gene 866 words KG: MAP1B 2026-03-24
kind:genesection:genesstate:published
Contents

MAP1B Gene

🧬 Gene Info
Gene SymbolMAP1B
Full NameMicrotubule Associated Protein 1B
AliasesMicrotubule-Associated Protein 1B
Chromosome5q13.2
Protein FamilyMAP1 family
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressiondeveloping neurons
Subcellular LocalizationAxons, growth cones, synaptic terminals, dendrites
Molecular Weight300 kDa
Amino Acids2700 aa
PathwaysAutophagy, NF-kB signaling
UniProt IDP46821
GeneCardsMAP1B
Human Protein AtlasMAP1B
Associated DiseasesAD, ALI, AMI, Als, NMO, RA
InteractionsMAP6, MAP2, UBIQUITIN, LC3, TAU, SAP97
KG Connections63 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.48
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Quantum Coherence Disruption in Cellular Communication
Score: 0.34

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Dynein Motor Protein
mechanism · KG edge: transports
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: implicated_in
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
MACF1 — Microtubule-actin crosslinking factor 1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MAP1B interacts_with MAP6
MAP1B interacts_with MAP2
MAP1B regulates GABARAP
MAP1B implicated_in NMO
MAP1B interacts_with UBIQUITIN
MAP1B associated_with NBR1
MAP1B interacts_with LC3
MAP1B interacts_with TAU
MAP1B transports TAU
MAP1B transports DYNEIN