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Home / Wiki / Entity: PSD-95 (Postsynaptic Density Protein 95)

entity 1,511 words KG: PSD-95 2026-03-24

kind:entity section:entities state:published

Contents

PSD-95 (Postsynaptic Density Protein 95)

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95
Score: 0.69 Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53 Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68 Vagal Afferent Microbial Signal Modulation
Score: 0.52 Vocal Cord Neuroplasticity Stimulation
Score: 0.50

SASP-Mediated Complement Cascade Amplification
Score: 0.70 Transcriptional Autophagy-Lysosome Coupling
Score: 0.66 Senescence-Activated NAD+ Depletion Rescue
Score: 0.60 Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56 Purinergic Signaling Polarization Control
Score: 0.55 Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.55 Senescent Cell Mitochondrial DNA Release
Score: 0.54 APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54 Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53 Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53 Phase-Separated Organelle Targeting
Score: 0.52 Membrane Cholesterol Gradient Modulators
Score: 0.52 Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51 Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51 Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51 Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.49 Stress Granule Phase Separation Modulators
Score: 0.49 Lysosomal Enzyme Trafficking Correction
Score: 0.49 Orexin-Microglia Modulation Therapy
Score: 0.49 Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.48 Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.48 Complement C1q Mimetic Decoy Therapy
Score: 0.48 Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48 TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47 Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47

Related Analyses (27)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived 4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived Synaptic pruning by microglia in early AD
neurodegeneration · archived Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
neuroscience · archived Epigenetic reprogramming in aging neurons
neurodegeneration · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (6)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40 s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40 Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40 Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40 tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40

Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40

See Also (13)

CREB-independent Neuronal Survival Pathways
mechanism · KG edge: activates APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates MAP2 Gene
gene · KG edge: activates LDLR Gene
gene · KG edge: activates ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1
gene · KG edge: activates

DLG4 Gene - PSD-95
gene · KG edge: associated_with CYP46A1 — Cholesterol 24-Hydroxylase
gene · KG edge: activates CD68 Gene
gene · KG edge: expressed_in BDNF Gene
gene · KG edge: activates ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates NMDA Receptor
entity · KG edge: activates glutamate
general · KG edge: activates GFAP (Redirect)
redirect · KG edge: activates

Knowledge Graph (12 edges)

PSD-95 associated_with BDNF signaling

PSD-95 regulates BDNF signaling

PSD-95 interacts_with SAP97

PSD-95 regulates GluR-A

PSD-95 interacts_with NEUREXIN

PSD-95 interacts_with NEUROLIGIN

PSD-95 interacts_with SHANK

PSD-95 involved_in excitatory synapses

PSD-95 activates Hippocampus

PSD-95 activates Neuroinflammatory

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