gene 2,144 words KG: SUST 2026-03-27
kind:genesection:genesstate:published
Contents

SUMF1 - Sulfatase Modifying Factor 1

🧬 Gene Info
Gene SymbolSUMF1
Full NameSulfatase Modifying Factor 1
AliasesPage for SUMF1 Protein
Chromosome2q33.1
FunctionThe SUMF1 protein, also known as formylglycine-generating enzyme (FGE), catalyzes the conversion of a conserved cysteine residue to formylglycine (FGly) in the active site of all sulfatases.
Primary ExpressionBrain, Liver, Kidney, Lung
Molecular Weight42 kDa
Amino Acids345 aa
Exons9
Pathwaysoxidative stress response
UniProt IDQ8IWU6
NCBI Gene ID285362
Ensembl IDENSG00000144455
OMIM272300
GeneCardsSUMF1
Human Protein AtlasSUMF1
Associated DiseasesMultiple Sulfatase Deficiency
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66

Related Analyses (28)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (5)

TP53 Gene
gene · KG edge: associated_with
RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-
gene · KG edge: associated_with
MET - MET Proto-Oncogene, Receptor Tyrosine Kinase
gene · KG edge: associated_with
MAP2K1 Gene
gene · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (8 edges)

SUST associated_with TP53
SUST associated_with MET
SUST associated_with MAP2K1
SUST associated_with RAF1
SUST associated_with GPR91
SUST associated_with PP2C
SUST associated_with HGF
SUST associated_with LZTR1