gene 699 words KG: TRPC1 2026-03-24
kind:genesection:genesstate:published
Contents

TRPC1 Gene

🧬 Gene Info
Gene SymbolTRPC1
Full NameTransient Receptor Potential Cation Channel Subfamily C Member 1
Chromosome3q23
Protein TypeChannel
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionUbiquitous - Brain, Heart, Skeletal muscle, Endothelium
Molecular Weight90 kDa
Amino Acids793 aa
Exons13
UniProt IDP48995
NCBI Gene ID7220
Ensembl IDENSG00000113615
OMIM602409
GeneCardsTRPC1
Human Protein AtlasTRPC1
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Stroke
InteractionsTRPV4, FSP1, PIEZO1, KCNK2, Rb, GENES
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Extracellular Matrix Stiffness Modulation
Score: 0.43

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

DEX effects on K2P channel transcriptome in mouse TM cells
exploratory · proposed · Score: 0.90

See Also (7)

TRPV4 Gene
gene · KG edge: activates
PIEZO1 — Piezo Type Mechanosensitive Ion Channel Compon
gene · KG edge: activates
KCNK2 Gene
gene · KG edge: activates
FSP1 Gene - Ferroptosis Suppressor Protein 1
gene · KG edge: activates
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

TRPC1 inhibits TRPV4
TRPC1 activates TRPV4
TRPC1 activates FSP1
TRPC1 activates PIEZO1
TRPC1 activates KCNK2
TRPC1 co_discussed TRPV4
TRPC1 activates Rb
TRPC1 activates neuroinflammation
TRPC1 activates Hypertension
TRPC1 activates GENES