gene 779 words KG: TRPV4 2026-03-24
kind:genesection:genesstate:published
Contents

TRPV4 Gene

🧬 Gene Info
Gene SymbolTRPV4
Full NameTransient Receptor Potential Cation Channel Subfamily V Member 4
Chromosome12q24.11
Protein TypeChannel
Functionof 871 amino acids with a molecular weight of approximately 98 kDa
Primary ExpressionCerebral cortex, Hippocampus, Dorsal root ganglion, Peripheral nerves, Endothelial cells
Molecular Weight98 kDa
Amino Acids871 aa
Exons15
PathwaysAkt, Angiogenesis, Blood-Brain Barrier, Er Stress, Mitophagy
UniProt IDQ9HBA0
NCBI Gene ID59341
Ensembl IDENSG00000167799
OMIM605067
GeneCardsTRPV4
Human Protein AtlasTRPV4
Associated DiseasesALS, Aging, Alzheimer, Blood-CNS Barrier Disruption, Cancer
Known Drugs/CompoundsCBD, cannabidiol
InteractionsFSP1, KCNK2, PIEZO1, MTOR, AKT, Mechanosensitive Ion Channel
KG Connections306 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Extracellular Matrix Stiffness Modulation
Score: 0.43
CYP46A1 Overexpression Gene Therapy
Score: 0.63
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Purinergic Signaling Polarization Control
Score: 0.55
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54

Related Analyses (7)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

DEX effects on K2P channel transcriptome in mouse TM cells
exploratory · proposed · Score: 0.90

See Also (9)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: co_discussed
CACNA1C Gene
gene · KG edge: associated_with
CACNA1B Gene
gene · KG edge: associated_with
ATF4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TRPV4 associated_with CACNA1B
TRPV4 associated_with SCNN1A
TRPV4 associated_with CFTR
TRPV4 associated_with PIEZO2
TRPV4 associated_with TRPA1
TRPV4 associated_with KCNMA1
TRPV4 associated_with TRPV1
TRPV4 associated_with KCNN4
TRPV4 associated_with KCNQ1
TRPV4 expressed_in CACNA1C