concept

FOXO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

203Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	FOXO
Summary	FOXO signaling in Alzheimer's, Parkinson's, and ALS
Key Genes/Proteins	AKT, FAS, BCL2L1, BNIP3, BCL2L11
Related Diseases	Stress Resistance, apoptosis
Related Pathways	adipogenesis, Pi3K/Akt Pathway, PI3K/AKT, autophagy pathway, ubiquitin-proteasome
Linked Hypotheses	2 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FOXO["FOXO"]
    style FOXO fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FOXO -.->|"inhibits"| adipogenesis["adipogenesis"]
    FOXO -->|"mediates"| Stress_Resistance(Stress Resistance)
    FOXO -->|"mediates"| G1_phase_Cell_Cycle_Arrest["G1-phase Cell Cycle Arrest"]
    FOXO -->|"activates"| apoptosis(apoptosis)
    FOXO -->|"activates"| FAS([FAS])
    FOXO -->|"activates"| BCL2L1([BCL2L1])
    FOXO -->|"activates"| BNIP3([BNIP3])
    FOXO -->|"activates"| BCL2L11([BCL2L11])
    FOXO -->|"activates"| ALS["ALS"]
    FOXO -.->|"inhibits"| Cancer["Cancer"]
    AKT([AKT]) -.->|"inhibits"| FOXO
    n_5A["5A"] -.->|"inhibits"| FOXO
    Pi3K_Akt_Pathway["Pi3K/Akt Pathway"] -->|"regulates"| FOXO
    SIRT1([SIRT1]) -->|"interacts"| FOXO
    AMPK([AMPK]) -->|"activates"| FOXO
    SIRT3([SIRT3]) -->|"activates"| FOXO
    MITOCHONDRIAL_DNA([MITOCHONDRIAL DNA]) -->|"activates"| FOXO
    MITOCHONDRIA([MITOCHONDRIA]) -->|"activates"| FOXO
    APOPTOSIS([APOPTOSIS]) -->|"activates"| FOXO

Outgoing (144)

Target	Relation	Type	Str
adipogenesis	inhibits	pathway	0.90
Stress Resistance	mediates	phenotype	0.85
G1-phase Cell Cycle Arrest	mediates	process	0.85
autophagy pathway	participates_in	pathway	0.80
apoptosis	activates	phenotype	0.80
FAS	activates	gene	0.80
BCL2L1	activates	gene	0.80
BNIP3	activates	gene	0.80
BCL2L11	activates	gene	0.80
ubiquitin-proteasome	participates_in	pathway	0.70
ALS	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Aging	interacts_with	disease	0.65
ALS	regulates	disease	0.65
Senescence	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Als	inhibits	disease	0.65
unfolded protein response	participates_in	pathway	0.65
NAD+ metabolism	participates_in	pathway	0.65
AMPK	causes	gene	0.60
DNA	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
HER2	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
BAD	inhibits	gene	0.60
JNK	inhibits	gene	0.60
DR5	inhibits	gene	0.60
Apoptosis	activates	pathway	0.60
Cell Cycle	activates	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
P53	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
AGING	interacts_with	gene	0.60

Incoming (59)

Source	Relation	Type	Str
AKT	inhibits	protein	0.90
AKT	phosphorylates	entity	0.85
Pi3K/Akt Pathway	regulates	pathway	0.85
5A	inhibits	compound	0.85
PI3K/AKT	regulates	pathway	0.85
SIRT1	interacts_with	gene	0.80
AMPK	activates	protein	0.64
SIRT3	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
ERK	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
MEK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
JUN	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MTOR	interacts_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MTOR	activates	gene	0.60
NF-ΚB	activates	gene	0.60
PRKAA1	activates	gene	0.60
PRKAA1/2	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
GSK3	activates	gene	0.60
GLUT1	activates	gene	0.60
MTORC1	activates	gene	0.60
AKT	activates	gene	0.60
CAMKII	activates	gene	0.60
DR5	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ULK1	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
NEURON	inhibits	gene	0.60
FUS	inhibits	gene	0.60
TDP-43	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
ALS	inhibits	gene	0.60
TARDBP	therapeutic_target	gene	0.60
ALS	regulates	gene	0.60
AKT	associated_with	gene	0.60
AKT	regulates	gene	0.60
AKT	targets	gene	0.60
APOE4	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FOXO3-Longevity Pathway Epigenetic Reprogramming	0.386	neurodegeneration	Epigenetic clocks and biological aging i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096]	Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li	Autophagy	2023	1
Fifteen-minute consultation: Therapeutic hypothermia for infants with hypoxic is [PMID:31292147]	Cawley P, Chakkarapani E	Arch Dis Child Educ Pract Ed	2020	1
Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve reg [PMID:30135423]	Sahoo PK, Lee SJ, Jaiswal PB, Alber S, K	Nat Commun	2018	1
EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. [PMID:28814570]	Yang C, Wu J, de Heus C, Grigoriev I, Li	J Cell Biol	2017	1
c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Dif [PMID:26694615]	Ishibashi R, Kozuki S, Kamakura S, Sumim	J Biol Chem	2016	1
DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperate [PMID:24652652]	Polato F, Rusconi P, Zangrossi S, Morell	J Natl Cancer Inst	2014	1
IRF4 addiction in multiple myeloma. [PMID:18568025]	Shaffer AL, Emre NC, Lamy L, Ngo VN, Wri	Nature	2008	1
Guishen-erxian decoction can improve ovarian function in rats with premature ova [PMID:40931880]	Zhong H, He Y, Wang W, Liu Y, Chen D et	Histol Histopathol	2026	0
Metabolic surgery mitigates early kidney injury in obese youth with diabetes by [PMID:41665972]	Naik AS, Alakwaa FM, Nair V, McCown PJ,	J Clin Invest	2026	0
FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by [PMID:41860561]	Wu ZL, Ran R, Xie QQ, Zhang C, Chen YJ e	Aging Cell	2026	0
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activat [PMID:41891498]	Xu J, Wan W, Mu H, Gong S, Liu Y et al.	J Biochem Mol Toxicol	2026	0
IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macr [PMID:41918304]	Ma Y, Gan S, Zheng Y, Kang X, Zhu S	Korean J Pain	2026	0
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579]	Wu K, Wang N, Zhao D, Wei W, Zhang W et	Zhejiang Da Xue Xue Bao Yi Xue	2026	0
Genome-wide association study and pathway analysis of healthy aging in Super Sen [PMID:41964836]	Hoque R, Leach S, Brooks-Wilson A	Geroscience	2026	0
Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoc [PMID:40106360]	Zhang W, Li W, Du J, Yang C, Yu L, Yang	Proceedings of the National Ac	2025	0
Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic [PMID:40634825]	Wei P, Zhang X, Yan C, Sun S, Chen Z, Li	Biogerontology	2025	0
The multifaceted impact of physical exercise on FoxO signaling pathways. [PMID:40861274]	Liu W, Meng P, Li Z, Shen Y, Meng X, Jin	Frontiers in cell and developm	2025	0
Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567]	["Porzuczek J"]	Sensors (Basel, Switzerland)	2024	0
Banxia Xiexin Decoction Prevents HT22 Cells from High Glucose-induced Neurotoxic [PMID:37608672]	["Shi Y", "Sheng P", "Guo M", "Chen K",	Current computer-aided drug de	2024	0
Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3. [PMID:36252111]	Zhu D, Liu S, Huang K, Wang Z, Hu S, Li	Circulation research	2022	0

FOXO

Understanding Entity Pages

Wiki Pages (21)

FOXO Signaling Pathway in Neurodegeneration

cbs-psp-daily-action-plan

NTF4 Protein

Growth Factor Therapies

Insulin Signaling in Parkinson's Disease

IGF-1 Signaling Pathway in Neurodegeneration

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

Lipid Peroxidation in Neurodegeneration

FOXO1 Protein

Transcriptional Regulation in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

TGF-β Signaling in Parkinson's Disease

Neurogenesis and Neurodegeneration

Type 3 Diabetes Hypothesis of Alzheimer's Disease

CNTFR Gene

FOXO4 — Forkhead Box O4

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease

RNASEK — Ribonuclease Kappa

Apoptosis in Neurodegeneration