gene 556 words KG: UBE3A 2026-03-21
kind:genesection:genesstate:published
Contents

UBE3A Gene

🧬 Gene Info
Gene SymbolUBE3A
Full NameUbiquitin Protein Ligase E3A
Chromosome15q11-q13
FunctionE3 ubiquitin ligase; protein quality control
Primary ExpressionBrain (neurons), widespread peripheral tissue
Subcellular Localization. The protein localizes to multiple cellular compartments including the cytoplasm, nucleus, and synaptic terminals, allo
Molecular Weight100 kDa
Amino Acids865 aa
PathwaysEr Stress, Innate Immunity, Mitophagy
UniProt IDQ05086
NCBI Gene ID7332
Ensembl IDENSG00000114062
OMIM601623
GeneCardsUBE3A
Human Protein AtlasUBE3A
Associated Diseasesneurodegeneration
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45
CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed

See Also (13)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: regulates
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: contributes_to
ER Stress and Unfolded Protein Response in Corticobasal
mechanism · KG edge: regulates
PINK1 — PTEN Induced Kinase 1 (PARK6)
gene · KG edge: regulates
NFKBIA Gene (NFKB Inhibitor Alpha)
gene · KG edge: contributes_to

Knowledge Graph (12 edges)

UBE3A contributes_to CREB3
UBE3A regulates PARKIN
UBE3A regulates UBIQUITIN
UBE3A regulates PARK6
UBE3A contributes_to MAPK8
UBE3A contributes_to NFKBIA
UBE3A regulates GFAP
UBE3A regulates PINK1
UBE3A regulates VCP
UBE3A regulates ALPHA-SYNUCLEIN