gene 1,509 words KG: MAPK8
Contents

MAPK8 Gene

🧬 Gene Info
Gene SymbolMAPK8
Full NameMitogen-Activated Protein Kinase 8
Chromosome10q11.22.
Protein FamilyMAPK (Mitogen-Activated Protein Kinases)
Protein TypeSerine/Threonine Kinase
FunctionMechanism
Molecular Weight46 kDa
Amino Acids427 aa
PathwaysMAPK, NF-κB
UniProt IDP45985
NCBI Gene ID5599
Ensembl IDENSG00000106789
GeneCardsMAPK8
Human Protein AtlasMAPK8
Alternative NameJNK1
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compoundsrapamycin, Polyphenols
InteractionsRHOT1, BNIP3L, NDP52, HIF1A, MAP1LC3B, GBA
KG Connections641 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
PARP1 Inhibition Therapy
Score: 0.58
Phase-Separated Organelle Targeting
Score: 0.52

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (5)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

MAPK8 activates MFN1
MAPK8 activates MIRO1
MAPK8 activates MUL1
MAPK8 activates NBR1
MAPK8 activates NDP52
MAPK8 activates NLRP3
MAPK8 activates OPTINEURIN
MAPK8 activates OPTN
MAPK8 activates P62
MAPK8 activates PARL