gene 552 words KG: PARK6 2026-03-24
kind:genesection:genesstate:published
Contents

PINK1 — PTEN Induced Kinase 1 (PARK6)

🧬 Gene Info
Gene SymbolPARK6
Full NamePINK1 — PTEN Induced Kinase 1 (PARK6)
AliasesPTEN Induced Kinase 1 (PARK6)
Chromosome1p36.23.
Protein TypeGene
Functionis a serine/threonine-protein kinase encoded by the PINK1 gene, located on chromosome 1p36.
Subcellular Localizationthe outer mitochondrial membrane and plays a critical role in mitochondrial quality control through the activation of pa
PathwaysEr Stress, Innate Immunity, Mapk, Mitophagy
NCBI Gene IDSearch NCBI
GeneCardsPARK6
Human Protein AtlasPARK6
Associated DiseasesALS, Neurodegeneration, Parkinson
KG Connections45 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (5)

Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.42
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived

Related Experiments (7)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

See Also (15)

Ubiquitin
protein · KG edge: associated_with
Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: regulates
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: regulates
ER Stress and Unfolded Protein Response in Corticobasal
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

PARK6 regulates MAPK8
PARK6 regulates NFKBIA
PARK6 regulates GFAP
PARK6 associated_with PINK1
PARK6 associated_with PRKN
PARK6 associated_with UBIQUITIN
PARK6 associated_with PARKIN
PARK6 associated_with PARK2
PARK6 causes PARK7
PARK6 causes PINK1