gene 1,763 words KG: WWTR1 2026-03-24
kind:genesection:genesstate:published
Contents

WWTR1 (TAZ) — WW Domain Containing Transcription Regulator 1, Hippo Effector

🧬 Gene Info
Gene SymbolWWTR1
Full NameWW Domain Containing Transcription Regulator 1
AliasesWW Domain Containing Transcription Regulator 1, Hippo Effector
Chromosome3q25.1
Functionencodes a 400 amino acid transcriptional co-activator that functions as a central effector of the Hippo signaling pathway.
Primary Expressionneural progenitor cells, with high levels in the ventricular zone and subventricular zone
Molecular Weight42.8 kDa
Amino Acids400 aa
Exons7
Ensembl IDENSG00000018408
GeneCardsWWTR1
Human Protein AtlasWWTR1
RUNX2/3Regulates osteogenic and chondrogenic differentiation
TBX5Cardiac development; mutations disrupting TAZ–TBX5 interaction cause congenital heart defects
SMAD2/3Integrates TGF-β signaling with Hippo pathway output
Associated DiseasesAls
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: contributes_to
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: contributes_to
Packard Center for ALS Research
institution · KG edge: associated_with
YAP1 — Yes-Associated Protein 1
gene · KG edge: contributes_to
LMNA Gene
gene · KG edge: contributes_to

Knowledge Graph (11 edges)

WWTR1 contributes_to Heart Failure
WWTR1 contributes_to Cardiovascular
WWTR1 associated_with Als
WWTR1 contributes_to Cardiac
WWTR1 contributes_to Ms
WWTR1 contributes_to Apoptosis
YAP1 contributes_to WWTR1
LMNA contributes_to WWTR1
HIPPO contributes_to WWTR1
APOPTOSIS contributes_to WWTR1