gene 1,339 words KG: YAP1 2026-03-24
kind:genesection:genesstate:published
Contents

YAP1 — Yes-Associated Protein 1

🧬 Gene Info
Gene SymbolYAP1
Full NameYes-Associated Protein 1
Chromosome11q22.1.
FunctionNeural development: YAP1 is essential for neural progenitor cell proliferation and maintenance of the neural stem cell pool during cortical development.
Primary ExpressionHippocampus, Cortex, Cerebellum, Substantia nigra (widespread)
Molecular Weight54 kDa
Exons9
PathwaysWnt, TGF-β, Notch
UniProt IDP46937
NCBI Gene ID10413
Ensembl IDENSG00000137693
OMIM606608
GeneCardsYAP1
Human Protein AtlasYAP1
Symbol [@lee2019] YAP1 [@sahu2022] [@pan2010] [@huang2021] Full Name [@fu2023] Yes-Associated Protein 1 Chromosome11q22.1
Associated DiseasesAls, Cancer, Carcinoma, Tumor
InteractionsPTEN, GBM, MYC, MET, SLC7A11, BMAL1
KG Connections195 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Phase-Separated Organelle Targeting
Score: 0.52
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (2)

Silibinin-induced G2/M cell cycle arrest in breast cancer ce
exploratory · proposed · Score: 0.90
Direct targeting of Capza1 by silibinin
exploratory · proposed · Score: 0.85

See Also (15)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: regulates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
GLI Gene Family
gene · KG edge: activates
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

YAP1 activates LOX
YAP1 activates PTEN
YAP1 activates GBM
YAP1 activates MYC
YAP1 activates MET
YAP1 therapeutic_target RB1
YAP1 activates SLC7A11
YAP1 activates BMAL1
YAP1 activates GPX4
YAP1 activates ARNT