gene 893 words KG: LMNA 2026-03-24
kind:genesection:genesstate:published
Contents

LMNA Gene

🧬 Gene Info
Gene SymbolLMNA
Chromosome1q22
Protein TypeProtein
Function### Nuclear Lamina Structure
Primary ExpressionUniversal (all cell types)
Molecular Weight72 kDa
Amino Acids33 aa
Exons12
Pathwayscalcium_homeostasis
UniProt IDP02545
NCBI Gene ID3999
Ensembl IDENSG00000160789
OMIM150330
GeneCardsLMNA
Human Protein AtlasLMNA
Associated DiseasesAD, ALI, ALS, AMI, Aging
InteractionsAPH1B, APOE, IL6, SREBF1, PSEN2, A2M
KG Connections836 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

LMNA activates MAP1LC3B
LMNA activates MAPK8
LMNA activates MFN1
LMNA activates MIRO1
LMNA activates MUL1
LMNA activates NBR1
LMNA activates NDP52
LMNA activates NLRP3
LMNA activates OPTINEURIN
LMNA activates OPTN