gene 2,563 words KG: XCL1 2026-03-27
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:neuroinflammation
Contents

XCL1 — X-C Motif Chemokine Ligand 1

🧬 Gene Info
Gene SymbolXCL1
Full NameX-C Motif Chemokine Ligand 1 (Lymphotactin)
Aliaseslymphotactin
Chromosome1q24.2
Functionis a 93-amino acid chemokine belonging to the unique C-class (also called XC family).
Primary ExpressionCD8+ T cells, NK cells, activated dendritic cells, brain microglia
Amino Acids93 aa
UniProt IDP47992
NCBI Gene ID10578
Ensembl IDENSG00000143184
OMIM300443
GeneCardsXCL1
Human Protein AtlasXCL1
ReceptorXCR1 (CXCR1)
Chemokine ClassC-class (lymphotactin)
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections4 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

See Also (15)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: expressed_in
EP300 Gene
gene · KG edge: therapeutic_target
Neurodegeneration
disease · KG edge: implicated_in
ALS Therapeutic Landscape — Programs by Phase and Modal
disease · Pages share 3 hypotheses

Knowledge Graph (4 edges)

XCL1 expressed_in Als
XCL1 therapeutic_target Carcinoma
XCL1 therapeutic_target Wnt
EP300 therapeutic_target XCL1