| Gene Symbol | EP300 |
| Chromosome | 22q13.2 |
| Protein Type | Transferase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Ubiquitous, highest in brain |
| Molecular Weight | ~300 kDa |
| Amino Acids | 414 aa |
| Pathways | NF-κB |
| GeneCards | EP300 |
| Human Protein Atlas | EP300 |
| Protein Size | 2,414 amino acids |
| Approach | Mechanism |
| HDAC Inhibitors | Increase histone acetylation |
| CBP/p300-specific inhibitors | Modulate transcription |
| Small molecule activators | Enhance p300 activity |
| Associated Diseases | Als, Alzheimer, Autoimmune, CANCER, Carcinoma |
| Known Drugs/Compounds | Acetyl-CoA, rapamycin |
| Interactions | FGFR3, TCF3, IGF2BP2, CSF1R, SMAD3, BRD4 |
| KG Connections | 578 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |