| Gene Symbol | KDM5A |
| Full Name | Lysine Specific Demethylase 5A |
| Aliases | Lysine Specific Demethylase 5A (JARID1A |
| Chromosome | 12p13.33 |
| Protein Family | JARID1 family (Jumonji C domain demethylase) |
| Function | This activity positions KDM5A as a transcriptional repressor that silences gene expression programs [[klose2006]](https://pubmed.ncbi.nlm.nih.gov/17110336/). |
| Pathways | Developmental Gene Regulation, Developmental Regulation |
| UniProt ID | Q9UMM3 |
| NCBI Gene ID | 8248 |
| Ensembl ID | ENSG00000150109 |
| OMIM | 180388 |
| GeneCards | KDM5A |
| Human Protein Atlas | KDM5A |
| H3K9me2/me3 demethylation | KDM5A can also target H3K9 methylation marks, which are typically associated with gene silencing, thereby modulating chromatin accessibility [[iwase2007]](https://pubmed.ncbi.nlm.nih.gov/17634180/). |
| Response to cellular stress | KDM5A participates in neuronal stress responses by regulating genes involved in apoptosis, DNA repair, and protein quality control [[zhang2016]](https://pubmed.ncbi.nlm.nih.gov/26630756/). |
| Associated Diseases | Aging, ALS, Diabetes, Ferroptosis |
| Interactions | CHD4, NURD COMPLEX, PARP1 |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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