Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHD4 is a protein involved in neurodegeneration research. Key relationships include: associated with, biomarker for, regulates. Associated with ALS, Als, Cancer. Connected to 28 entities in the SciDEX knowledge graph.
| Gene Symbol | CHD4 |
| Full Name | Chromodomain Helicase DNA Binding Protein 4 |
| Chromosome | 12p12.3 |
| Function | CHD4 encodes a member of the chromodomain helicase family (CHD) that functions as an ATP-dependent chromatin remodeler. |
| Primary Expression | the central nervous system: |
| Molecular Weight | 226 kDa |
| UniProt ID | Q14839 |
| NCBI Gene ID | 2298 |
| Ensembl ID | ENSG00000124177 |
| OMIM | 605602 |
| GeneCards | CHD4 |
| Human Protein Atlas | CHD4 |
| Encoded Protein | Chromodomain helicase DNA-binding protein 4 (Mi-2 beta) |
| Associated Diseases | ALS, Migraine |
| Interactions | CHIP, KDM5A |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CHD4["<b>CHD4</b>"]
Als{"Als"}
CHD4 -->|"regulates"| Als
CHD4 -->|"biomarker for"| Als
Ms{"Ms"}
CHD4 -->|"biomarker for"| Ms
Cancer{"Cancer"}
CHD4 -->|"biomarker for"| Cancer
Carcinoma{"Carcinoma"}
CHD4 -->|"biomarker for"| Carcinoma
Migraine{"Migraine"}
CHD4 -->|"associated with"| Migraine
ALS{"ALS"}
CHD4 -->|"regulates"| ALS
GENES["GENES"]
CHD4 -->|"regulates"| GENES
KDM5A["KDM5A"]
CHD4 -->|"regulates"| KDM5A
Proteasome(["Proteasome"])
CHD4 -->|"biomarker for"| Proteasome
HMGCR["HMGCR"]
CHD4 -->|"associated with"| HMGCR
TGFB3["TGFB3"]
CHD4 -->|"associated with"| TGFB3
KDM5A -->|"regulates"| CHD4
MIRNAS["MIRNAS"]
MIRNAS -->|"biomarker for"| CHD4
SP1["SP1"]
SP1 -->|"biomarker for"| CHD4
CANCER["CANCER"]
CANCER -->|"biomarker for"| CHD4
RPS6KB1["RPS6KB1"]
RPS6KB1 -->|"biomarker for"| CHD4
KCNK5["KCNK5"]
KCNK5 -->|"associated with"| CHD4
TGFB1["TGFB1"]
TGFB1 -->|"associated with"| CHD4
TP53["TP53"]
TP53 -->|"associated with"| CHD4
NR1D1["NR1D1"]
NR1D1 -->|"associated with"| CHD4
FXN["FXN"]
FXN -->|"associated with"| CHD4
EPHA5["EPHA5"]
EPHA5 -->|"associated with"| CHD4
EP300["EP300"]
EP300 -->|"associated with"| CHD4
style CHD4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| H3K4 Methylation | modulates | entity | 0.85 |
| Als | regulates | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Cancer | biomarker_for | disease | 0.65 |
| Carcinoma | biomarker_for | disease | 0.65 |
| Migraine | associated_with | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| KDM5A | regulates | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| TGFB3 | associated_with | gene | 0.60 |
| Rb | regulates | protein | 0.60 |
| MC3R | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| Proteasome | biomarker_for | pathway | 0.60 |
| AND | regulates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| KDM5A | co_expressed_with | protein | 0.50 |
| CHIP | activates | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| KDM5A | interacts_with | protein | 0.85 |
| KDM5A | regulates | gene | 0.60 |
| SP1 | biomarker_for | gene | 0.60 |
| RPS6KB1 | biomarker_for | gene | 0.60 |
| KCNK5 | associated_with | gene | 0.60 |
| TGFB1 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| NR1D1 | associated_with | gene | 0.60 |
| FXN | associated_with | gene | 0.60 |
| EPHA5 | associated_with | gene | 0.60 |
| EP300 | associated_with | gene | 0.60 |
| NLGN2 | associated_with | gene | 0.60 |
| CDK4 | associated_with | gene | 0.60 |
| ATXN3 | regulates | gene | 0.60 |
| MIRNAS | biomarker_for | gene | 0.60 |
| CANCER | biomarker_for | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||