protein

CHD4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections
0Hypotheses
0Analyses
20Outgoing
18Incoming

Summary

CHD4 is a protein involved in neurodegeneration research. Key relationships include: associated with, biomarker for, regulates. Associated with ALS, Als, Cancer. Connected to 28 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolCHD4
Full NameChromodomain Helicase DNA Binding Protein 4
Chromosome12p12.3
FunctionCHD4 encodes a member of the chromodomain helicase family (CHD) that functions as an ATP-dependent chromatin remodeler.
Primary Expressionthe central nervous system:
Molecular Weight226 kDa
UniProt IDQ14839
NCBI Gene ID2298
Ensembl IDENSG00000124177
OMIM605602
GeneCardsCHD4
Human Protein AtlasCHD4
Encoded ProteinChromodomain helicase DNA-binding protein 4 (Mi-2 beta)
Associated DiseasesALS, Migraine
InteractionsCHIP, KDM5A
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CHD4 — AlphaFold Q14839 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CHD4 Gene

gene · 665 words

Epigenetic Dysregulation in Neurodegeneration

mechanism · 4376 words

chromatin-remodeling-neurodegeneration

mechanism · 3216 words

Chromatin Remodeling in Neurodegeneration

mechanism · 3115 words

RAD21 — Cohesin Complex Component in Neurodegeneration

gene · 3046 words

Epigenetics in Amyotrophic Lateral Sclerosis

mechanism · 2479 words

Pathway Diagram

graph TD
    CHD4["<b>CHD4</b>"]
    Als{"Als"}
    CHD4 -->|"regulates"| Als
    CHD4 -->|"biomarker for"| Als
    Ms{"Ms"}
    CHD4 -->|"biomarker for"| Ms
    Cancer{"Cancer"}
    CHD4 -->|"biomarker for"| Cancer
    Carcinoma{"Carcinoma"}
    CHD4 -->|"biomarker for"| Carcinoma
    Migraine{"Migraine"}
    CHD4 -->|"associated with"| Migraine
    ALS{"ALS"}
    CHD4 -->|"regulates"| ALS
    GENES["GENES"]
    CHD4 -->|"regulates"| GENES
    KDM5A["KDM5A"]
    CHD4 -->|"regulates"| KDM5A
    Proteasome(["Proteasome"])
    CHD4 -->|"biomarker for"| Proteasome
    HMGCR["HMGCR"]
    CHD4 -->|"associated with"| HMGCR
    TGFB3["TGFB3"]
    CHD4 -->|"associated with"| TGFB3
    KDM5A -->|"regulates"| CHD4
    MIRNAS["MIRNAS"]
    MIRNAS -->|"biomarker for"| CHD4
    SP1["SP1"]
    SP1 -->|"biomarker for"| CHD4
    CANCER["CANCER"]
    CANCER -->|"biomarker for"| CHD4
    RPS6KB1["RPS6KB1"]
    RPS6KB1 -->|"biomarker for"| CHD4
    KCNK5["KCNK5"]
    KCNK5 -->|"associated with"| CHD4
    TGFB1["TGFB1"]
    TGFB1 -->|"associated with"| CHD4
    TP53["TP53"]
    TP53 -->|"associated with"| CHD4
    NR1D1["NR1D1"]
    NR1D1 -->|"associated with"| CHD4
    FXN["FXN"]
    FXN -->|"associated with"| CHD4
    EPHA5["EPHA5"]
    EPHA5 -->|"associated with"| CHD4
    EP300["EP300"]
    EP300 -->|"associated with"| CHD4
    style CHD4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

TargetRelationTypeStr
H3K4 Methylationmodulatesentity0.85
Alsregulatesdisease0.65
Alsbiomarker_fordisease0.65
Msbiomarker_fordisease0.65
Cancerbiomarker_fordisease0.65

Incoming (18)

SourceRelationTypeStr
KDM5Ainteracts_withprotein0.85
KDM5Aregulatesgene0.60
SP1biomarker_forgene0.60
RPS6KB1biomarker_forgene0.60
KCNK5associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found