protein

P53

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2651Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

P53 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 1671 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	P53
Pathways	Aging
GeneCards	P53
Human Protein Atlas	P53
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	RAPAMYCIN, chemotherapy, Thiabendazole, MDM2 antagonist Nutlin-3, APR-246, stapled peptides
Interactions	AMPK, BECN1, RPTOR, HTRA2, ULK1, PRKAA2
KG Connections	2628 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    P53["P53"] -->|"activates"| PUMA["PUMA"]
    P53["P53"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    P53["P53"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    P53["P53"] -->|"regulates"| CELL_CYCLE["CELL_CYCLE"]
    P53["P53"] -->|"mediates"| ALS["ALS"]
    P53["P53"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    TP53["TP53"] -->|"encodes"| P53["P53"]
    POLY_PR["POLY_PR"] -->|"activates"| P53["P53"]
    SF3B1["SF3B1"] -->|"therapeutic target"| P53["P53"]
    TERT["TERT"] -->|"therapeutic target"| P53["P53"]
    style P53 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1589)

Target	Relation	Type	Str
PUMA	activates	protein	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Apoptosis	activates	pathway	1.00
Tumor	associated_with	disease	1.00
Tumor	regulates	disease	1.00
Cancer	activates	disease	1.00
Ferroptosis	regulates	pathway	1.00
Aging	activates	disease	1.00
Tumor	inhibits	disease	1.00
Cancer	inhibits	disease	1.00
Tumor	therapeutic_target	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	activates	disease	1.00
Ferroptosis	activates	pathway	1.00
Cancer	expressed_in	disease	1.00
Als	regulates	disease	1.00
Inflammation	regulates	disease	1.00
Apoptosis	regulates	pathway	1.00
Tumor	activates	disease	1.00
Mtor	regulates	pathway	1.00
Apoptosis	inhibits	pathway	1.00
Cancer	associated_with	disease	1.00
Als	associated_with	disease	1.00
Als	inhibits	disease	1.00
Aging	therapeutic_target	disease	1.00
Autophagy	activates	pathway	1.00
Nf-Κb	activates	pathway	1.00
Senescence	regulates	disease	1.00
Cell Cycle	inhibits	pathway	1.00
Dna Repair	inhibits	pathway	1.00
Inflammation	activates	disease	1.00
GENES	regulates	gene	1.00
DNA	regulates	gene	1.00
INFLAMMATION	regulates	gene	1.00
CANCER	therapeutic_target	gene	1.00
Als	interacts_with	disease	1.00
CANCER	inhibits	gene	1.00
CANCER	activates	gene	1.00
CANCER	associated_with	gene	1.00
Carcinoma	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
Inflammation	inhibits	disease	1.00
FERROPTOSIS	activates	gene	1.00
MDM2	activates	gene	1.00
Apoptosis	therapeutic_target	pathway	1.00
Cancer	regulates	disease	1.00
AKT	regulates	gene	1.00
AKT	activates	gene	1.00
Senescence	inhibits	disease	1.00

Incoming (1062)

Source	Relation	Type	Str
DNA	inhibits	gene	1.00
TP53	therapeutic_target	gene	1.00
SLC7A11	activates	gene	1.00
PI3K	associated_with	gene	1.00
GENES	inhibits	gene	1.00
SIRT1	activates	gene	1.00
BAX	activates	gene	1.00
TP53	inhibits	gene	1.00
TP53	regulates	gene	1.00
PI3K	activates	gene	1.00
TP53	expressed_in	gene	1.00
CANCER	activates	gene	1.00
ROS	activates	gene	1.00
CANCER	expressed_in	gene	1.00
APOPTOSIS	regulates	gene	1.00
CYTOKINES	activates	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
NF-ΚB	activates	gene	1.00
CANCER	inhibits	gene	1.00
ROS	inhibits	gene	1.00
APOPTOSIS	inhibits	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
CANCER	regulates	gene	1.00
MDM2	binds_to	protein	0.95
POLY(PR)	activates	protein	0.90
ribosomal proteins	activates	protein	0.90
SNORA13	upstream_of	process	0.90
STAU1	activates	protein	0.90
MDM2 antagonist Nutlin-3	activates	drug	0.90
APR-246	activates	drug	0.90
DRAGO (KIAA0247)	cooperates_with	gene	0.90
GPX4	activates	gene	0.90
GENES	activates	gene	0.90
TNF	inhibits	gene	0.90
AMPK	activates	gene	0.90
TP53	activates	gene	0.90
NEURODEGENERATION	associated_with	gene	0.90
STAT3	activates	gene	0.90
NEURODEGENERATION	regulates	gene	0.90
PI3K	regulates	gene	0.90
NEURODEGENERATION	inhibits	gene	0.90
PARKINSON'S DISEASE	activates	gene	0.90
PARKINSON	activates	gene	0.90
CANCER	treats	gene	0.90
SIRT1	downregulates	protein	0.89
Thiabendazole	modulates	drug	0.85

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.562	neurodegeneration	What upstream mechanisms trigger p53 act

Mentioning Analyses (1)

Scientific analyses that reference this entity

What upstream mechanisms trigger p53 activation specifically in response to poly

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.562

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

P53

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

calcium-dysregulation-comparison

NPM1 Gene

GSK-3β in Neurodegeneration

Epigenetic Dysregulation in Neurodegeneration

Ferroptosis in Alzheimer's Disease

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

Excitotoxicity in Neurodegeneration

RPL30 — Ribosomal Protein L30 in Neurodegeneration

Protein Aggregation Comparison in Neurodegeneration

Angelman Syndrome

PEN2 Gene

Non-Homologous End Joining in Neurodegeneration

DNA Damage Response in Parkinson's Disease

TYNDASE — Tyndall

Microglial Senescence Pathway in Neurodegeneration

DNA Damage Response in Corticobasal Syndrome

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

DNA Damage Response Impairment Pathway