protein

P53

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2579Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

9Debates

Summary

P53 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 1671 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	P53
Subcellular Localization	</th><td>Nucleus (transcription factor)</td></tr>
Pathways	Aging
GeneCards	P53
Human Protein Atlas	P53
N-terminal Transactivation Domain (TAD)	Contains two subdomains (TAD1, TAD2) for transcriptional activation
Proline-Rich Domain (PRD)	Mediates protein-protein interactions
Central DNA-Binding Domain (DBD)	Binds to p53 response elements (p53 RE) as a tetramer
Oligomerization Domain (OD)	Forms tetramers essential for DNA binding
C-terminal Regulatory Domain (CTD)	Modulates DNA binding and contains nuclear localization signals
Cell Cycle Arrest	Activates p21 to halt cell cycle progression
[Apoptosis](/entities/apoptosis)	Induces pro-apoptotic genes (BAX, PUMA, NOXA)
DNA Repair	Upregulates DNA repair proteins
Senescence	Induces cellular senescence programs
Metabolism	Modulates glycolysis and oxidative phosphorylation
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	APR-246, chemotherapy, Emodin, MDM2 antagonist Nutlin-3, rapamycin, RAPAMYCIN
Interactions	ACAT1, ACETYL-COA, ACOX1, ACSL4, Actin, ACVR2A
KG Connections	2543 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    P53["P53"] -->|"activates"| PUMA["PUMA"]
    P53["P53"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    P53["P53"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    P53["P53"] -->|"regulates"| CELL_CYCLE["CELL_CYCLE"]
    P53["P53"] -->|"mediates"| ALS["ALS"]
    P53["P53"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    TP53["TP53"] -->|"encodes"| P53["P53"]
    POLY_PR["POLY_PR"] -->|"activates"| P53["P53"]
    SF3B1["SF3B1"] -->|"therapeutic target"| P53["P53"]
    TERT["TERT"] -->|"therapeutic target"| P53["P53"]
    style P53 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1545)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:P53	data_in	dataset_row	0.00
P53	encodes	protein	0.00
Mtor	activates	pathway	1.00
GENES	inhibits	gene	1.00
Ferroptosis	regulates	pathway	1.00
Cell Cycle	inhibits	pathway	1.00
CANCER	activates	gene	1.00
Cancer	activates	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Dna Repair	inhibits	pathway	1.00
Cancer	regulates	disease	1.00
Als	inhibits	disease	1.00
FERROPTOSIS	regulates	gene	1.00
Inflammation	inhibits	disease	1.00
Stem Cell	activates	pathway	1.00
FERROPTOSIS	activates	gene	1.00
AKT	activates	gene	1.00
Tumor	regulates	disease	1.00
AKT	regulates	gene	1.00
MDM2	activates	gene	1.00
DNA	inhibits	gene	1.00
Als	therapeutic_target	disease	1.00
AGING	activates	gene	1.00
Senescence	regulates	disease	1.00
Autophagy	activates	pathway	1.00
Tumor	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
Nf-Κb	activates	pathway	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
INFLAMMATION	regulates	gene	1.00
Aging	therapeutic_target	disease	1.00
Oxidative Stress	inhibits	pathway	1.00
Neurodegeneration	activates	disease	1.00
CANCER	associated_with	gene	1.00
GENES	activates	gene	1.00
PUMA	activates	protein	1.00
Invasion	activates	pathway	1.00
Cancer	associated_with	disease	1.00
Apoptosis	inhibits	pathway	1.00
Glycolysis	activates	pathway	1.00
Aging	activates	disease	1.00
Als	interacts_with	disease	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Cancer	expressed_in	disease	1.00
Tumor	inhibits	disease	1.00
Cell Cycle	activates	pathway	1.00
Als	treats	disease	1.00
Als	associated_with	disease	1.00

Incoming (1034)

Source	Relation	Type	Str
P53	encodes	gene	0.00
benchmark_ot_ad_answer_key:P53	data_in	dataset_row	0.00
SLC7A11	activates	gene	1.00
CANCER	targets	gene	1.00
TP53	expressed_in	gene	1.00
CANCER	expressed_in	gene	1.00
DNA	inhibits	gene	1.00
TP53	inhibits	gene	1.00
BAX	activates	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
PI3K	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
GENES	inhibits	gene	1.00
TP53	therapeutic_target	gene	1.00
CYTOKINES	activates	gene	1.00
ROS	activates	gene	1.00
TP53	regulates	gene	1.00
CANCER	activates	gene	1.00
SIRT1	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
PI3K	activates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
NF-ΚB	activates	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
APOPTOSIS	regulates	gene	1.00
CANCER	inhibits	gene	1.00
ROS	inhibits	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
CANCER	regulates	gene	1.00
MDM2	associated_with	protein	0.95
DRAGO (KIAA0247)	cooperates_with	gene	0.90
POLY(PR)	activates	protein	0.90
MDM2	regulates	gene	0.90
MDM2	inhibits	protein	0.90
poly(PR)	activates	protein	0.90
SIRT1	deacetylates	enzyme	0.90
SIRT1	modulates	enzyme	0.90
SIRT1	regulates	enzyme	0.90
RBM28	binds	protein	0.90
APR-246	activates	drug	0.90
MDM2	interacts_with	protein	0.90
STAU1	activates	protein	0.90
SNORA13	upstream_of	process	0.90
ribosomal proteins	activates	protein	0.90
MDM2 antagonist Nutlin-3	activates	drug	0.90
CANCER	treats	gene	0.90
TNF	inhibits	gene	0.90
NEURODEGENERATION	regulates	gene	0.90
TP53	activates	gene	0.90
PI3K	regulates	gene	0.90

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ATM Kinase Hyperactivation Triggers DNA Damage Response Over	0.837	als	-
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.661	neurodegeneration	What upstream mechanisms trigger p53 act

Mentioning Analyses (2)

Scientific analyses that reference this entity

What upstream mechanisms trigger p53 activation specifically in response to poly

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.661

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.769

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (9)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning P53 in their description or question text

No additional research found

P53

Understanding Entity Pages

Summary

Wiki Pages (6)

Tumor Protein P53

TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

DJ-1-PTEN-P53 Network

TP53 Gene

TIGAR Protein — TP53-Induced Glycolysis and Apoptosis Regulator

TP53 Protein (p53)

Pathway Diagram

Outgoing (1545)

Incoming (1034)

Targeting Hypotheses (2)

Mentioning Analyses (2)

What upstream mechanisms trigger p53 activation specifically in response to poly

Senescent cell clearance as neurodegeneration therapy

Experiments (0)

Related Papers (0)

Debates (9)

Extended debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

The abstract shows p53 is a central regulator of C9orf72-mediated neurodegenerat

Senescent cell clearance as neurodegeneration therapy

Related Research