gene 1,307 words KG: KDM5A
Contents

KDM5A (Lysine Specific Demethylase 5A)

🧬 Gene Info
Gene SymbolKDM5A
Full NameLysine Specific Demethylase 5A
AliasesLysine Specific Demethylase 5A (JARID1A
Chromosome12p13.33
Protein FamilyJARID1 family (Jumonji C domain demethylase)
FunctionThis activity positions KDM5A as a transcriptional repressor that silences gene expression programs [[klose2006]](https://pubmed.ncbi.nlm.nih.gov/17110336/).
PathwaysDevelopmental Gene Regulation, Developmental Regulation
UniProt IDQ9UMM3
NCBI Gene ID8248
Ensembl IDENSG00000150109
OMIM180388
GeneCardsKDM5A
Human Protein AtlasKDM5A
AliasJARID1A, RBP2, PLU1
Associated DiseasesALS, Aging, Diabetes, Ferroptosis
InteractionsPARP1, AND, NURD COMPLEX, CHD4
KG Connections40 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
PARP1 Inhibition Therapy
Score: 0.58
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE-TREM2 Interaction Modulation
Score: 0.48

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: regulates
CTSB Gene
gene · KG edge: associated_with
CHD4 Gene
gene · KG edge: interacts_with
CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A
gene · KG edge: associated_with

Knowledge Graph (12 edges)

KDM5A regulates CHD4
KDM5A upregulates TREM2
KDM5A regulates HOXA5
KDM5A activates Wnt/β-catenin pathway
KDM5A inhibits Wnt/β-catenin pathway
KDM5A regulates p53
KDM5A interacts_with PARP1
KDM5A catalyzes H3K4 Methylation
KDM5A regulates Transcriptional Activation
KDM5A involved_in Developmental Regulation