| Name | Blood-Brain Barrier Breakdown as Primary Disease Driver |
| Summary | Comprehensive analysis of blood-brain barrier (BBB) breakdown as a primary driver of neurodegeneration, covering pericyte loss, astrocyte detachment, tight junction degradation, MMP9 activation, peripheral immune infiltration, and therapeutic strategies across AD, PD, and ALS. |
| Key Genes/Proteins | HSPA1A, HSPA1B |
| Linked Hypotheses | 5 hypotheses |