Contents

Ribonuclease κ and Circular RNAs: A New Mechanism of Aging and Neurodegeneration

🔬 Protein Info

Gene Symbol	ent-gene-173851ef
Backsplicing	The 5' end of an exon connects to the 3' end of the same or a different exon
Covalent closure	Forms a stable covalently closed circular molecule
No cap/tail	Produces circular molecules lacking 5' caps and 3' tails
CDR1as (ciRS-7)	Contains 74 miR-7 binding sites, acts as an effective miR-7 sponge[@piwecka2017]
Sry circRNA	Contains 16 miR-135 binding sites[@hansen2013a]
circHIPK3	Sponges multiple miRNAs including miR-124
RNA binding protein (RBP) sequestration	Bind and sequester RBPs
Transcription factor interference	Trap transcription factors
Splicing factor modulation	Affect spliceosome function
Internal ribosome entry sites (IRES)	Enable cap-independent translation
circRNA-encoded peptides	Produce novel protein isoforms
Disease association	Translation products linked to disease states[@pamudurti2017]
RNA polymerase II regulation	Modulate transcriptional activity
Epigenetic modifications	Affect chromatin modifications
Parent gene expression	Regulate expression of host genes
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph