Contents

p-tau

🔬 Protein Info

Gene Symbol	TAU
Chromosome	17q21.31
Protein Family	MAPT family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, where they bind to microtubules and promote their polymerization and stability
Subcellular Localization	Axons, Neurons
Molecular Weight	45-65 kDa (isoform dependent)
Amino Acids	441 aa
Pathways	Extracellular Aggregation, Hyperphosphorylation, Neurofibrillary Tangle Formation, Protein Assembly, Synapse Pathology
GeneCards	TAU
Human Protein Atlas	TAU
First characterized	2012
Primary use	Research use; emerging marker with limited clinical data
Source	CSF, plasma
Specificity	Distinguishes AD from frontotemporal dementia, Lewy body dementia, and vascular dementia with ~85% accuracy[@hansson2022]
Associated Diseases	ALZHEIMER, alzheimers_disease, Alzheimer's disease, apoptosis, frontotemporal_dementia, hippocampal atrophy
Known Drugs/Compounds	EGCG, rutin, Urolithin A
Interactions	Amyloid-β, APOE4, ASK1, Aβ, CDK5, GSK-3β
SciDEX Hypotheses	TREM2 should remain under review until replicated APOE should remain under review until replicated GFAP should remain under review until replicated (+2 more)
KG Connections	139 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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