concept

ASK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ASK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

117Connections

0Hypotheses

0Analyses

50Outgoing

16Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ASK1
Related Diseases	Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease, ALZHEIMER'S_DISEASE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ASK1["ASK1"]
    ASK1 -->|"regulates"| Neuronal_Apoptosis["Neuronal Apoptosis"]
    ASK1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    ASK1 -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    ASK1 -->|"contributes to"| Parkinson_s_Disease["Parkinson's Disease"]
    ASK1 -->|"contributes to"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ASK1 -->|"contributes to"| Huntington_s_Disease["Huntington's Disease"]
    Oxidative_Stress["Oxidative Stress"] -->|"activates"| ASK1
    Endoplasmic_Reticulum_Stress["Endoplasmic Reticulum Stress"] -->|"activates"| ASK1
    SOD1["SOD1"] -->|"activates"| ASK1
    HTT["HTT"] -->|"activates"| ASK1
    SNCA["SNCA"] -->|"activates"| ASK1
    ER_stress["ER_stress"] -->|"activates"| ASK1
    oxidative_stress["oxidative_stress"] -->|"activates"| ASK1

Outgoing (101)

Target	Relation	Type	Str
Neuronal Apoptosis	regulates	process	0.95
Neuroinflammation	regulates	process	0.95
Neuronal Apoptosis	activates	process	0.95
APOPTOSIS	regulates	process	0.95
NEUROINFLAMMATION	regulates	process	0.95
NEURODEGENERATION	contributes_to	process	0.95
Neuroinflammation	modulates	process	0.92
Alzheimer's Disease	contributes_to	disease	0.90
Parkinson's Disease	contributes_to	disease	0.90
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.90
Huntington's Disease	contributes_to	disease	0.90
Neuroinflammation	mediates	process	0.90
Amyotrophic Lateral Sclerosis	involved_in	disease	0.90
ALZHEIMER'S_DISEASE	associated_with	disease	0.90
PARKINSON'S_DISEASE	associated_with	disease	0.90
ALS	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
Parkinson's Disease	associated_with	disease	0.90
Tau Hyperphosphorylation	causes	process	0.85
Amyloid-Beta-Induced Neurotoxicity	mediates	process	0.85
Dopaminergic Neuron Degeneration	causes	process	0.85
Multiple Sclerosis	contributes_to	disease	0.85
Motor Neuron Degeneration	causes	phenotype	0.85
Oxidative Stress	associated_with	process	0.85
Tau Hyperphosphorylation	mediates	process	0.85
TAU	phosphorylates	protein	0.85
NEURON	mediates	cell_type	0.85
INFLAMMATION	modulates	process	0.85
MKK7	phosphorylates	protein	0.85
Motor Neuron Degeneration	associated_with	process	0.85
Amyloid-Beta-Induced Neurotoxicity	involved_in	process	0.85
Huntington's Disease	associated_with	disease	0.85
Multiple Sclerosis	associated_with	disease	0.85
Demyelination	involved_in	process	0.80
Tau Hyperphosphorylation	contributes_to	phenotype	0.80
MKK7	activates	gene	0.80
neurodegeneration	implicated_in	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
Parkinson's disease	implicated_in	disease	0.80
Huntington's disease	implicated_in	disease	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
amyloid-beta	contributes_to	compound	0.80
tau	contributes_to	protein	0.80
dopaminergic neurons	causes_apoptosis_of	cell_type	0.80
motor neurons	causes_degeneration_of	cell_type	0.80
demyelination	contributes_to	biological_process	0.80
neuronal injury	contributes_to	phenotype	0.80
MKK6	activates	protein	0.75
apoptosis pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70

Incoming (16)

Source	Relation	Type	Str
Oxidative Stress	activates	process	0.90
Endoplasmic Reticulum Stress	activates	process	0.90
OXIDATIVE_STRESS	activates	process	0.90
Endoplasmic_Reticulum_Stress	activates	process	0.90
Ginsenoside Compound K	targets	compound	0.90
SOD1	activates	gene	0.85
HTT	activates	gene	0.85
APP	interacts_with	protein	0.85
SNCA	activates	gene	0.80
APP	mediates	protein	0.75
ER_stress	activates	phenotype	0.64
oxidative_stress	activates	phenotype	0.64
ALS	causes	gene	0.60
ALS	activates	gene	0.60
AKT	activates	gene	0.60
ASC	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ASK1

Understanding Entity Pages

Wiki Pages (20)

Neurotrophin Signaling Pathways in Neurodegeneration

er-stress-neurodegeneration

Unfolded Protein Response (UPR)

Demyelination

MAPK/ERK Signaling Pathway in Neurodegeneration

PRDX2 — Peroxiredoxin 2

endoplasmic-reticulum-stress

jnk-p38-mapk-parkinsons

ER Stress in Corticobasal Syndrome

MEKK3 Protein

JNK/p38 MAPK Signaling Pathway in Neurodegeneration

PI3K/Akt Activator Clinical Trials for Parkinson's Disease

CBS ER Stress and Unfolded Protein Response Mechanisms

PRDX1 (Peroxiredoxin 1)

LRP1-ApoE Signaling Cascade

CASP12 Gene — Cysteine-Containing Aspartate-Specific Protease 12

CRYAB Gene

txnip