| Gene Symbol | TAU |
| Chromosome | 17q21.31 |
| Protein Family | MAPT family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons, where they bind to microtubules and promote their polymerization and stability |
| Subcellular Localization | Axons, Neurons |
| Molecular Weight | 45-65 kDa (isoform dependent) |
| Amino Acids | 441 aa |
| Pathways | Extracellular Aggregation, Hyperphosphorylation, Neurofibrillary Tangle Formation, Protein Assembly, Synapse Pathology |
| GeneCards | TAU |
| Human Protein Atlas | TAU |
| First characterized | 2012 |
| Primary use | Research use; emerging marker with limited clinical data |
| Source | CSF, plasma |
| Specificity | Distinguishes AD from frontotemporal dementia, Lewy body dementia, and vascular dementia with ~85% accuracy[@hansson2022] |
| Associated Diseases | ALZHEIMER, Alzheimer's disease, apoptosis, neurodegeneration |
| Known Drugs/Compounds | rutin, Urolithin A, EGCG |
| Interactions | Amyloid-β, APOE4, heat shock proteins, GSK-3β, ASK1, p38 MAPK |
| KG Connections | 83 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |