| Gene Symbol | ADAMTS |
| Full Name | 4 Protein |
| Aliases | ADAMTS4PROTEIN |
| Function | The catalytic domain coordinates a zinc ion through three histidine residues (H369, H373, H379) and a glutamate (E370) acts as the general base for catalysis. |
| Subcellular Localization | ** | Secreted, extracellular space | |
| GeneCards | ADAMTS |
| Human Protein Atlas | ADAMTS |
| Transcriptional | NF-κB, AP-1, and RUNX2 control gene expression in response to inflammatory signals |
| Endogenous inhibitors | TIMP-3 is the primary physiological inhibitor; binds the catalytic domain with nanomolar affinity |
| Substrate availability | ECM composition and CSPG accessibility determine activity |
| C-terminal processing | Removal of the spacer domain by MT4-MMP generates a more active truncated enzyme with broader substrate specificity |
| Interactions | SMAD3, BMAL1, Rb, BIN1, AGING, AND |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |