| Gene Symbol | ADNP |
| Aliases | ADNPPROTEIN |
| Protein Type | Transcription Factor |
| Function | ADNP encodes a 1,102 amino acid protein containing a homeobox domain, nine zinc fingers, and a PxVxL motif that mediates interaction with the SWI/SNF chromatin remodeling complex through HP1. |
| Subcellular Localization | </td><td>Nucleus, cytoplasm, extracellular</td></tr> |
| Molecular Weight | 124 kDa |
| Amino Acids | 102 aa |
| Pathways | Autophagy, Epigenetic, Wnt |
| Ensembl ID | ENSG00000101126 |
| GeneCards | ADNP |
| Human Protein Atlas | ADNP |
| SH3 domain-binding region | Mediates direct interaction with tau and FYN kinase |
| Phosphorylation | Multiple serine/threonine phosphorylation sites regulate nuclear-cytoplasmic shuttling and chromatin binding |
| SUMOylation | SUMO modification at Lys-809 modulates transcriptional activity |
| Proteolytic processing | ADNP can be cleaved to release bioactive fragments including the NAP peptide |
| Associated Diseases | Aging, Ms, autism spectrum disorder |
| Interactions | SIRT1, TAU, LC3, P2X7, SNF, SWI |
| KG Connections | 85 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |