disease

autism spectrum disorder

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about autism spectrum disorder: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

192Connections
0Hypotheses
1Analyses
12Outgoing
50Incoming

No summary available yet. View on Wiki →

Disease Info
CategoryGenetic/Complex
Associated GenesNLGN1, PVALB, CYP19A1, PRRG4, RhoA, DNA, ALS, FTLD
Therapeutic Agentsrapamycin, curcumin
KG Connections179 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

GRIA3 Gene

gene · 5408 words

Microglial Cells — Cell Type Hierarchy

cell · 5150 words

CNTN5 — Contactin 5

gene · 4980 words

Autophagy Mechanisms

mechanism · 4866 words

Pathway Diagram

graph TD
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| pyroptosis["pyroptosis"]
    style pyroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| apoptosis_pathway["apoptosis pathway"]
    style apoptosis_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| ubiquitin_proteasome["ubiquitin-proteasome"]
    style ubiquitin_proteasome fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| MAPK_signaling["MAPK signaling"]
    style MAPK_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Disease_Associated_Microglia["Disease-Associated Microglia"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
    style Disease_Associated_Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Tuberous_Sclerosis_Complex_Ass["Tuberous Sclerosis Complex-Associated Epilepsy"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
    style Tuberous_Sclerosis_Complex_Ass fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
    style Microbiota_Gut_Brain_Axis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ROS["ROS"] -->|"activates"| autism_spectrum_disorder["autism spectrum disorder"]
    style ROS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NLRP3["NLRP3"] -->|"activates"| autism_spectrum_disorder["autism spectrum disorder"]
    style NLRP3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style autism_spectrum_disorder fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (12)

TargetRelationTypeStr
pyroptosisinvolvespathway0.90
oxidative stress responseinvolvespathway0.90
apoptosis pathwayinvolvespathway0.80
necroptosisinvolvespathway0.70
PI3K-AKT-mTOR signalinginvolvespathway0.70

Incoming (180)

SourceRelationTypeStr
GSDMDinteracts_withgene0.90
NLRP3interacts_withgene0.90
HNRNP MUTATIONSassociated_withgene0.82
ROSactivatesgene0.80
NLRP3activatesgene0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found