Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about autism spectrum disorder: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Category | Genetic/Complex |
| Associated Genes | NLGN1, PVALB, CYP19A1, PRRG4, RhoA, DNA, ALS, FTLD |
| Therapeutic Agents | rapamycin, curcumin |
| KG Connections | 179 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| pyroptosis["pyroptosis"]
style pyroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| oxidative_stress_response["oxidative stress response"]
style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| apoptosis_pathway["apoptosis pathway"]
style apoptosis_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| necroptosis["necroptosis"]
style necroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| ubiquitin_proteasome["ubiquitin-proteasome"]
style ubiquitin_proteasome fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| MAPK_signaling["MAPK signaling"]
style MAPK_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| ferroptosis["ferroptosis"]
style ferroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
Disease_Associated_Microglia["Disease-Associated Microglia"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
style Disease_Associated_Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Tuberous_Sclerosis_Complex_Ass["Tuberous Sclerosis Complex-Associated Epilepsy"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
style Tuberous_Sclerosis_Complex_Ass fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
style Microbiota_Gut_Brain_Axis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
ROS["ROS"] -->|"activates"| autism_spectrum_disorder["autism spectrum disorder"]
style ROS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
NLRP3["NLRP3"] -->|"activates"| autism_spectrum_disorder["autism spectrum disorder"]
style NLRP3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style autism_spectrum_disorder fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| pyroptosis | involves | pathway | 0.90 |
| oxidative stress response | involves | pathway | 0.90 |
| apoptosis pathway | involves | pathway | 0.80 |
| necroptosis | involves | pathway | 0.70 |
| PI3K-AKT-mTOR signaling | involves | pathway | 0.70 |
| ubiquitin-proteasome | involves | pathway | 0.60 |
| MAPK signaling | involves | pathway | 0.60 |
| ferroptosis | involves | pathway | 0.60 |
| NF-kB signaling | involves | pathway | 0.60 |
| mitochondrial function | involves | pathway | 0.60 |
| autophagy pathway | involves | pathway | 0.60 |
| JAK-STAT signaling | involves | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GSDMD | interacts_with | gene | 0.90 |
| NLRP3 | interacts_with | gene | 0.90 |
| HNRNP MUTATIONS | associated_with | gene | 0.82 |
| ROS | activates | gene | 0.80 |
| NLRP3 | activates | gene | 0.80 |
| GSDMD | activates | gene | 0.80 |
| NLRP3 | inhibits | gene | 0.80 |
| ASC | interacts_with | gene | 0.80 |
| RhoA | associated_with | protein | 0.75 |
| PV | expressed_in | gene | 0.70 |
| rapamycin | treats | drug | 0.70 |
| TLR4 | activates | gene | 0.70 |
| NLGN1 | associated_with | protein | 0.60 |
| PVALB | associated_with | protein | 0.60 |
| CYP19A1 | associated_with | gene | 0.60 |
| PRRG4 | implicated_in | gene | 0.60 |
| GSDME | activates | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| DNA | expressed_in | gene | 0.60 |
| GSDME | expressed_in | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
| FTLD | associated_with | gene | 0.60 |
| ATP | regulates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| ATP | interacts_with | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| WNT | expressed_in | gene | 0.60 |
| NLRP3 | regulates | gene | 0.60 |
| GSDMD | regulates | gene | 0.60 |
| MAPL | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| AIM2 | activates | gene | 0.60 |
| MLKL | activates | gene | 0.60 |
| ZBP1 | activates | gene | 0.60 |
| ADNP | protects_against | gene | 0.60 |
| TSC1 | interacts_with | gene | 0.60 |
| TSC2 | interacts_with | gene | 0.60 |
| PVALB | regulates | gene | 0.60 |
| MTNR1B | interacts_with | gene | 0.60 |
| NPAS2 | interacts_with | gene | 0.60 |
| PER2 | interacts_with | gene | 0.60 |
| PER1 | interacts_with | gene | 0.60 |
| MTNR1A | interacts_with | gene | 0.60 |
| CLOCK | associated_with | gene | 0.60 |
| MTNR1B | associated_with | gene | 0.60 |
| PER3 | associated_with | gene | 0.60 |
| NR1D1 | associated_with | gene | 0.60 |
| ARNTL | associated_with | gene | 0.60 |
| PER2 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||